Elon University, Elon, NC, USA.
University of North Carolina, Greensboro, NC, USA.
Eur J Sport Sci. 2020 Jul;20(6):819-830. doi: 10.1080/17461391.2019.1660726. Epub 2019 Sep 8.
Little is known about the biological mechanisms underlying the beneficial effect of acute exercise on memory or the influence of single nucleotide polymorphisms (SNPs) on this effect. Brain-derived neurotrophic factor (BDNF) is a putative biological mechanism, and while findings from human studies are equivocal, they have neglected to assess how exercise affects individual BDNF isoform (proBDNF, mBDNF) concentrations in serum or the influence of the val66met SNP on BDNF isoform concentrations. Therefore, the objective of this study was to conduct an exploratory assessment of the effect of acute exercise intensity on memory performance and BDNF isoform concentrations relative to carrier status of the val66met SNP met allele and to provide guidance for future, fully-powered trials. Memory and BDNF isoform concentrations were assessed in three exercise groups (light intensity, vigorous intensity, and non-exercise) relative to met carrier status. Analyses revealed that BDNF isoform concentrations and memory were differentially affected by exercise intensity and met carrier status. Vigorous intensity exercise increased mBDNF, and met carriers had lower mBDNF concentration. Light intensity exercise improved memory, and over 24 h, memory was worse for met carriers. Implications from this work will help direct future mechanistic studies of the exercise-memory relationship.
目前对于急性运动对记忆有益影响的生物学机制以及单核苷酸多态性 (SNP) 对这种影响的影响知之甚少。脑源性神经营养因子 (BDNF) 是一种推测的生物学机制，虽然来自人类研究的结果存在争议，但它们忽略了评估运动如何影响血清中单个 BDNF 同工型（proBDNF、mBDNF）的浓度以及 val66met SNP 对 BDNF 同工型浓度的影响。因此，本研究的目的是探索性地评估急性运动强度对记忆表现和 BDNF 同工型浓度的影响，相对于 val66met SNP met 等位基因的携带状态，并为未来的全功率试验提供指导。根据 met 携带状态，将记忆和 BDNF 同工型浓度分别评估在三个运动组（低强度、高强度和非运动）中。分析表明，BDNF 同工型浓度和记忆受运动强度和 met 携带状态的影响不同。高强度运动增加了 mBDNF，而 met 携带者的 mBDNF 浓度较低。低强度运动改善了记忆，并且在 24 小时内，met 携带者的记忆更差。这项工作的意义将有助于指导未来关于运动与记忆关系的机制研究。
