Nutrition, University of Buenos Aires, Buenos Aires, Argentina.
Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires-CONICET, Buenos Aires, Argentina.
Arch Med Res. 2019 Apr;50(3):98-104. doi: 10.1016/j.arcmed.2019.07.001. Epub 2019 Jul 26.
High altitude is associated with hypobaric hypoxia, and metabolic modifications. In particular, alterations to lipoprotein-associated enzymes have been reported under hypoxia.
To determine the association between paraoxonase 1 (PON-1) and Cholesteryl-ester transfer protein (CETP) activities and altitude in two groups of Argentinean Indigenous schoolchildren living at different altitudes.
A cross-sectional study compared 151 schoolchildren from San Antonio de los Cobres (SAC), 3,750 m, with 175 schoolchildren from Chicoana (CH), 1,400 m. Anthropometric data, lipids, apolipoprotein (apo) A-I, apo B, plus PON-1 and CETP activities were determined.
The prevalence of overweight/obesity was significantly lower in SAC than in CH. Z- BMI (0.3 vs 0.7), Apo A-I/Apo B (1.67 vs. 1.85) and PON-1 (170 vs. 243 nmol/mL.min) were significantly lower in SAC than in CH, respectively. Total cholesterol (156 vs 144 mg/dL), triglycerides (TG) (119 vs. 94 mg/dL), apo A-I (133 vs. 128 mg/dL), apo B (84 vs. 73 mg/dL), hematocrit (48 vs. 41%), transferrin (295 vs. 260 mg/dL) and CETP (181 vs. 150%/mL.h) were significantly higher in SAC than in CH. There was a significant univariate association between altitude and transferrin (r0.38), hematocrit (r0.75), TG (r0.24), apo B (r0.29), PON-1 (r-0.40), and CETP (r0.37). Multiple linear regression analyses showed that altitude was significantly associated with children's TG (β = 0.28, R = 0.14), HDL-C (β = ‒0.27; R = 0.23), apo B (β = 0.32; R = 0.14), CETP (β = 0.38; R = 0.15) and PON-1 (β = ‒0.36; R = 0.16), adjusted for age, gender and BMI.
SAC children presented a more atherogenic lipid profile, plus lower PON1 and higher CETP activities, than CH children.
高海拔与低气压缺氧和代谢改变有关。特别是在缺氧环境下，脂蛋白相关酶的变化已被报道。
在两组居住在不同海拔高度的阿根廷原住民学龄儿童中，确定对氧磷酶 1（PON-1）和胆固醇酯转移蛋白（CETP）活性与海拔之间的关系。
一项横断面研究比较了来自圣安东尼奥德洛斯科布雷斯（SAC）的 151 名学龄儿童（海拔 3750 米）和来自奇科阿纳（CH）的 175 名学龄儿童（海拔 1400 米）。测定了人体测量数据、血脂、载脂蛋白（apo）A-I、apo B、PON-1 和 CETP 活性。
SAC 组超重/肥胖的患病率明显低于 CH 组。Z-BMI（0.3 对 0.7）、apo A-I/apo B（1.67 对 1.85）和 PON-1（170 对 243 nmol/mL.min）分别显著低于 CH 组。SAC 组总胆固醇（156 对 144 mg/dL）、甘油三酯（TG）（119 对 94 mg/dL）、apo A-I（133 对 128 mg/dL）、apo B（84 对 73 mg/dL）、红细胞压积（48 对 41%）、转铁蛋白（295 对 260 mg/dL）和 CETP（181 对 150%/mL.h）均显著高于 CH 组。海拔与转铁蛋白（r0.38）、红细胞压积（r0.75）、TG（r0.24）、apo B（r0.29）、PON-1（r-0.40）和 CETP（r0.37）之间存在显著的单变量关联。多元线性回归分析显示，海拔与儿童 TG（β=0.28，R=0.14）、HDL-C（β=-0.27；R=0.23）、apo B（β=0.32；R=0.14）、CETP（β=0.38；R=0.15）和 PON-1（β=-0.36；R=0.16）显著相关，调整了年龄、性别和 BMI。
与 CH 组儿童相比，SAC 组儿童表现出更具动脉粥样硬化倾向的血脂谱，PON1 活性更低，CETP 活性更高。
