a University of Buenos Aires , Buenos Aires , Argentina.
b Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry , University of Buenos Aires-CONICET , Buenos Aires , Argentina.
Redox Rep. 2018 Dec;23(1):35-40. doi: 10.1080/13510002.2017.1370783. Epub 2017 Aug 30.
Children living at high altitude in San Antonio de los Cobres (SAC), Argentina, were shown to have lower high-density lipoprotein cholesterol (HDL-C) levels than Buenos Aires (BA) children. HDL antioxidant capacity is mainly attributed to paraoxonase1 (PON1).
To compare PON1 activity in indigenous SAC vs. BA children.
A cross-sectional study compared 158 SAC vs. 97 BA children (6-16 years). Anthropometric data and lipoprotein profile were measured. PON1 was evaluated employing paraoxon (PON) and phenylacetate (ARE) activity.
The prevalence of overweight/obesity was lower in SAC than in BA children (18.3 vs. 30.9%). Triglycerides (1.34 vs. 0.90 mmol/l), apo B (0.84 vs.0.72 g/l), apo A-I (1.33 vs. 1.27 g/l), and ARE activity (100 vs. 90 µmol/ml/min) were higher, while HDL-C (1.16 vs. 1.32 mmol/l) and PON activity (170 vs. 203 nmol/ml/min) were lower in SAC than in BA. Separate multiple linear regression analyses showed that SAC children had significantly higher triglyceride (Beta -0.38), apo B (Beta -0.34), and ARE (Beta -0.36) plus lower HDL-C (Beta 0.33) and PON (Beta 0.25) compared with BA; adjusted for age, gender, and BMI.
SAC showed an unfavorable lipoprotein profile, lower PON and higher ARE activities compared with BA children, suggesting the presence of altered HDL metabolism and antioxidant capacity.
研究显示，生活在阿根廷圣安东尼奥德洛斯科布雷斯（SAC）高海拔地区的儿童的高密度脂蛋白胆固醇（HDL-C）水平低于布宜诺斯艾利斯（BA）的儿童。高密度脂蛋白的抗氧化能力主要归因于对氧磷酶 1（PON1）。
比较 SAC 与 BA 儿童的 PON1 活性。
一项横断面研究比较了 158 名 SAC 儿童与 97 名 BA 儿童（6-16 岁）。测量了人体测量数据和脂蛋白谱。采用对氧磷（PON）和苯乙酸（ARE）活性评估 PON1。
SAC 儿童超重/肥胖的患病率低于 BA 儿童（18.3% vs. 30.9%）。SAC 儿童的甘油三酯（1.34 vs. 0.90mmol/l）、载脂蛋白 B（0.84 vs. 0.72g/l）、载脂蛋白 A-I（1.33 vs. 1.27g/l）和 ARE 活性（100 vs. 90µmol/ml/min）较高，而 HDL-C（1.16 vs. 1.32mmol/l）和 PON 活性（170 vs. 203nmol/ml/min）较低。独立的多元线性回归分析表明，与 BA 儿童相比，SAC 儿童的甘油三酯（Beta-0.38）、载脂蛋白 B（Beta-0.34）和 ARE（Beta-0.36）水平更高，HDL-C（Beta 0.33）和 PON（Beta 0.25）水平更低；校正年龄、性别和 BMI 后。
与 BA 儿童相比，SAC 显示出不利的脂蛋白谱，PON 活性较低，ARE 活性较高，提示存在 HDL 代谢和抗氧化能力改变。
