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G-proteins in the signal-transduction pathways of Dictyostelium discoideum.

作者信息

Snaar-Jagalska B E, Kesbeke F, Van Haastert P J

机构信息

Cell Biology and Genetics Unit, Zoological Laboratory, Leiden, The Netherlands.

出版信息

Dev Genet. 1988;9(4-5):215-26. doi: 10.1002/dvg.1020090404.

DOI:10.1002/dvg.1020090404
PMID:3149562
Abstract

The functional interaction of surface cAMP receptors with effector enzymes via G-proteins was investigated in Dictyostelium discoideum. Several experimental conditions were used to investigate signal transduction, such as reduced temperatures, use of down-regulated cells and of mutants. The results are presented as a model describing the complex interaction between multiple forms of the surface cAMP receptor and different G-proteins that are responsible for the generation of the second messengers, cAMP, cGMP, InsP3 and Ca2+.

摘要

相似文献

1
G-proteins in the signal-transduction pathways of Dictyostelium discoideum.
Dev Genet. 1988;9(4-5):215-26. doi: 10.1002/dvg.1020090404.
2
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A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement.一条依赖Gα的信号通路，该通路拮抗多种调节细胞定向运动的趋化因子反应。
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7
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引用本文的文献

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Selective induction of gene expression and second-messenger accumulation in Dictyostelium discoideum by the partial chemotactic antagonist 8-p-chlorophenylthioadenosine 3',5'-cyclic monophosphate.部分趋化性拮抗剂8-对氯苯硫基腺苷3',5'-环磷酸酯对盘基网柄菌基因表达和第二信使积累的选择性诱导作用
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9219-23. doi: 10.1073/pnas.88.20.9219.
2
The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase.盘基网柄菌丝裂原活化蛋白激酶激酶DdMEK1调节趋化作用，对于趋化因子介导的鸟苷酸环化酶激活至关重要。
EMBO J. 1997 Jul 16;16(14):4317-32. doi: 10.1093/emboj/16.14.4317.
3
Genetic networks that regulate development in Dictyostelium cells.
调控盘基网柄菌细胞发育的遗传网络。
Microbiol Rev. 1996 Mar;60(1):135-50. doi: 10.1128/mr.60.1.135-150.1996.
4
Dual role of cAMP and involvement of both G-proteins and ras in regulation of ERK2 in Dictyostelium discoideum.环磷酸腺苷（cAMP）的双重作用以及G蛋白和ras在盘基网柄菌中对细胞外信号调节激酶2（ERK2）调控中的参与
EMBO J. 1996 Jul 1;15(13):3361-8.
5
The surface cyclic AMP receptors, cAR1, cAR2, and cAR3, promote Ca2+ influx in Dictyostelium discoideum by a G alpha 2-independent mechanism.表面环磷酸腺苷受体cAR1、cAR2和cAR3通过一种不依赖Gα2的机制促进盘基网柄菌中的钙离子内流。
Mol Biol Cell. 1993 Mar;4(3):283-92. doi: 10.1091/mbc.4.3.283.
6
A G protein-based model of adaptation in Dictyostelium discoideum.基于G蛋白的盘基网柄菌适应性模型。
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7
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Mol Biol Cell. 1994 Jun;5(6):691-702. doi: 10.1091/mbc.5.6.691.
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A density-sensing factor regulates signal transduction in Dictyostelium.一种密度感应因子调节盘基网柄菌中的信号转导。
J Cell Biol. 1995 Jun;129(5):1251-62. doi: 10.1083/jcb.129.5.1251.
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cAMP-mediated inhibition of intracellular particle movement and actin reorganization in Dictyostelium.环磷酸腺苷（cAMP）介导的盘基网柄菌细胞内颗粒运动抑制及肌动蛋白重组
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10
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Mol Cell Biol. 1991 Jan;11(1):468-75. doi: 10.1128/mcb.11.1.468-475.1991.