Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Adv Mater. 2020 Apr;32(13):e1902005. doi: 10.1002/adma.201902005. Epub 2019 Sep 9.
Cell therapy has already had an important impact on healthcare and provided new treatments for previously intractable diseases. Notable examples include mesenchymal stem cells for tissue regeneration, islet transplantation for diabetes treatment, and T cell delivery for cancer immunotherapy. Biomaterials have the potential to extend the therapeutic impact of cell therapies by serving as carriers that provide 3D organization and support cell viability and function. With the growing emphasis on personalized medicine, cell therapies hold great potential for their ability to sense and respond to the biology of an individual patient. These therapies can be further personalized through the use of patient-specific cells or with precision biomaterials to guide cellular activity in response to the needs of each patient. Here, the role of biomaterials for applications in tissue regeneration, therapeutic protein delivery, and cancer immunotherapy is reviewed, with a focus on progress in engineering material properties and functionalities for personalized cell therapies.
细胞治疗已经对医疗保健产生了重要影响，并为以前难以治疗的疾病提供了新的治疗方法。值得注意的例子包括用于组织再生的间充质干细胞、用于糖尿病治疗的胰岛移植以及用于癌症免疫治疗的 T 细胞输送。生物材料有可能通过充当提供 3D 组织和支持细胞活力和功能的载体来扩展细胞治疗的治疗效果。随着人们越来越重视个性化医学，细胞治疗因其能够感知和响应个体患者的生物学特性而具有巨大的潜力。这些疗法可以通过使用患者特异性细胞或使用精密生物材料来进一步个性化，以响应每个患者的需求来指导细胞活动。在这里，我们回顾了生物材料在组织再生、治疗性蛋白输送和癌症免疫治疗中的应用，重点介绍了为个性化细胞治疗工程材料特性和功能方面的进展。
