Allerton Timothy D, Irving Brian A, Spielmann Guillaume, Primeaux Stefany, Landin Dennis, Nelson Arnold, Johannsen Neil M
Adipocyte Biology, Pennington Biomedical Research Center, Baton Rouge, Louisiana.
School of Kinesiology, Louisiana State University, Baton Rouge, Louisiana.
Physiol Rep. 2019 Sep;7(17):e14189. doi: 10.14814/phy2.14189.
We assessed metabolic flexibility (MF) via a mixed meal in a group of young, healthy participants with a positive family history of maternal type 2 diabetes (T2D) (FH+) and those without a family history of T2D (FH-) under three distinct conditions; baseline (BL; no previous exercise), 1-h post high intensity interval exercise (1H), and 48-h post exercise recovery. On separate visits, participants completed a single bout of high intensity interval exercise (HIIE) and repeated the MMTT 1-h (1H) and 48 h (48H) postexercise. FH+ participants were not able to suppress fat oxidation 1-h post exercise (1H) as effectively as FH- participants were, however, this response was improved when measured at the 48H visit. Insulin AUC was significantly lowered at both 1H and 48H when compared to the BL visit. Serum NEFA AUC was elevated 1-h post exercise, when compared to BL, but was significantly reduced at the 48H visit. Young, healthy participants with a maternal history of T2D demonstrate impaired MF (related to the inability to suppress fat oxidation) in response to acute HIIE (1H) that was improved 48H. The overall effect of HIIE showed improved insulin AUC and NEFA AUC up to 48H post that did not differ by FH.
我们通过混合餐评估了一组年轻健康参与者的代谢灵活性（MF），这些参与者中有2型糖尿病（T2D）家族史阳性（FH +）的，也有没有T2D家族史（FH-）的，评估在三种不同条件下进行：基线（BL；之前无运动）、高强度间歇运动后1小时（1H）以及运动后恢复48小时。在不同的访视中，参与者完成一次高强度间歇运动（HIIE），并在运动后1小时（1H）和48小时（48H）重复进行混合餐耐量试验（MMTT）。FH +参与者在运动后1小时（1H）不能像FH-参与者那样有效地抑制脂肪氧化，然而，在48H访视时测量，这种反应有所改善。与BL访视相比，胰岛素AUC在1H和48H时均显著降低。与BL相比，血清非酯化脂肪酸（NEFA）AUC在运动后1小时升高，但在48H访视时显著降低。有T2D家族史的年轻健康参与者在急性HIIE（1H）后表现出MF受损（与无法抑制脂肪氧化有关），而在48H时有所改善。HIIE的总体效果显示，直至运动后48小时胰岛素AUC和NEFA AUC均有所改善，且不受FH影响。
