Research Centre on Aging, Affiliated with CIUSSS de l'Estrie-CHUS, 1036, Rue Belvédère Sud, Sherbrooke, QC J1H 4C4, Canada.
Faculty of Physical Activity Sciences, University of Sherbrooke, 2500, Boul. De l'Université, Sherbrooke, QC J1K 2R1, Canada.
Nutrients. 2022 Nov 3;14(21):4638. doi: 10.3390/nu14214638.
Aging and family history of type 2 diabetes (T2D) are known risk factors of T2D. Younger first-degree relatives (FDR) of T2D patients have shown early metabolic alterations, which could limit exercise's ability to prevent T2D. Thus, the objective was to determine whether exercise metabolism was altered during submaximal exercise in FDR postmenopausal women. Nineteen inactive postmenopausal women (control: 10, FDR: 9) aged 60 to 75 years old underwent an incremental test on a cycle ergometer with intensity ranging from 40 to 70% of peak power output. Participants consumed 50 mg of C-palmitate 2 h before the test. At the end of each stage, glucose, lactate, glycerol, non-esterified fatty acids and C-palmitate were measured in plasma, and CO was measured in breath samples. Gas exchanges and heart rate were both monitored continuously. There were no between-group differences in substrate oxidation, plasma substrate concentrations or C recovered in plasma or breath. Interestingly, despite exercising at a similar relative intensity to control, FDR were consistently at a lower percentage of heart rate reserve. Overall, substrate plasma concentration and oxidation are not affected by family history of T2D in postmenopausal women and therefore not a participating mechanism in the altered response to exercise previously reported. More studies are required to better understand the mechanisms involved in this response.
年龄增长和 2 型糖尿病（T2D）家族史是 T2D 的已知危险因素。T2D 患者的年轻一级亲属（FDR）已经表现出早期的代谢改变，这可能限制了运动预防 T2D 的能力。因此，本研究的目的是确定绝经后 FDR 女性在亚最大运动期间的运动代谢是否发生改变。19 名不活跃的绝经后女性（对照组：10 名，FDR：9 名）年龄在 60 至 75 岁之间，在自行车测力计上进行递增测试，强度范围为峰值功率输出的 40%至 70%。参与者在测试前 2 小时内消耗 50 毫克 C-棕榈酸。在每个阶段结束时，测量血浆中的葡萄糖、乳酸、甘油、非酯化脂肪酸和 C-棕榈酸，并测量呼吸样本中的 CO。连续监测气体交换和心率。两组之间的底物氧化、血浆底物浓度或在血浆或呼吸中回收的 C 没有差异。有趣的是，尽管 FDR 的相对运动强度与对照组相似，但 FDR 的心率储备百分比始终较低。总的来说，在绝经后女性中，家族性 T2D 病史并不影响底物血浆浓度和氧化，因此不是先前报道的对运动反应改变的参与机制。需要更多的研究来更好地理解这种反应中涉及的机制。
