Fahim Mohamed Ibrahim, Nassar Omaya Abdelhamid, Mansour Osman Mohamed, Ali Abdelmaksoud Mohamed, Mahmoud Ahmed-Mostafa, Hafez Nesreen Hassan, Allam Rasha Mahmoud, Kamal Amr, Ghareeb Mohamed
1Surgical Oncology department, National Cancer Institute-Cairo University, 1 Kasr El-Aini Street, Foum El-Khalig, Cairo, 11796 Egypt.
2Medical Oncology department, National Cancer Institute-Cairo University, Cairo, Egypt.
Indian J Surg Oncol. 2019 Sep;10(3):417-421. doi: 10.1007/s13193-018-0867-y. Epub 2019 Jan 6.
Treatment by cytoreductive surgery (CRS) and intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) has been an option for selected patients with peritoneal carcinomatosis. This study aims to evaluate the impact of HIPEC in epithelial ovarian cancer (EOC). A retrospective observational cohort study including 48 EOC patients treated and followed up between 2012 and 2016. Thirty-seven cases were treated by CRS only, while 11 cases were treated by CRS and HIPEC. The study was performed at National Cancer Institute (NCI)-Cairo University. There was no statistically significant difference regarding overall survival or disease-free survival between the group of EOC patients treated by CRS only and the one treated by CRS and HIPEC. Presence of ascites and histological types (serous/non-serous) were the significant independent variables related to overall survival. Presence of ascites was the only independent variable associated with a significant relation to disease-free survival. No statistically significant impact of HIPEC in treatment of EOC was found in this study.
细胞减灭术（CRS）联合术中腹腔内热灌注化疗（HIPEC）已成为部分腹膜癌患者的一种治疗选择。本研究旨在评估HIPEC对上皮性卵巢癌（EOC）的影响。这是一项回顾性观察队列研究，纳入了2012年至2016年间接受治疗并随访的48例EOC患者。37例仅接受CRS治疗，11例接受CRS联合HIPEC治疗。该研究在开罗大学国家癌症研究所（NCI）进行。仅接受CRS治疗的EOC患者组与接受CRS联合HIPEC治疗的患者组在总生存期或无病生存期方面无统计学显著差异。腹水的存在和组织学类型（浆液性/非浆液性）是与总生存期相关的显著独立变量。腹水的存在是与无病生存期有显著关联的唯一独立变量。本研究未发现HIPEC对EOC治疗有统计学显著影响。
