Bajwa Asima, Burstein Eitan, Grainger Robert M, Netland Peter A
Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Department of Biology, University of Virginia , Charlottesville, VA, USA.
Clin Ophthalmol. 2019 Aug 6;13:1469-1473. doi: 10.2147/OPTH.S217930. eCollection 2019.
We performed a retrospective, comparative study to determine if patients with aniridia and glaucoma had open angles on high-resolution anterior segment optical coherence tomography (OCT) and clinical gonioscopy.
Forty-three patients (86 eyes) with aniridia had recorded anterior segment OCTs, gonioscopy, or both. Of these patients, 27 (54 eyes) were diagnosed with glaucoma and 16 (32 eyes) had no evidence of glaucoma. All patients had either anterior segment OCT, gonioscopy, or both.
The 43 patients with aniridia had average age of 32±17 years, and 27 (62%) were female. Anterior segment OCT and gonioscopy were recorded in 25 (58%) of the patients and 18 (42%) of the patients had gonioscopy alone. Of the 54 eyes with aniridia and glaucoma, 4 (7%) eyes in 3 patients (11%) had partial or completely closed angles. Of the 32 eyes without glaucoma, all (100%) had open angles. The proportion of open angles in the aniridia with glaucoma eyes was not significantly different compared with the aniridia without glaucoma eyes (=0.32). Of the 4 eyes with closed angles, all had a history of prior surgery for cataract, glaucoma, and/or keratopathy. The proportion of eyes with prior surgery was significantly higher in eyes with open-angle glaucoma and angle-closure glaucoma compared with eyes without glaucoma (<0.001 and =0.002, respectively).
The majority of eyes with aniridia and glaucoma have open anterior chamber angles, similar to patients with aniridia without glaucoma. All eyes with aniridia and glaucoma that had closed angles had a prior history of ocular surgery.
我们进行了一项回顾性比较研究，以确定无虹膜合并青光眼患者在高分辨率眼前节光学相干断层扫描（OCT）和临床前房角镜检查中房角是否开放。
43例（86只眼）无虹膜患者记录了眼前节OCT、前房角镜检查或两者均有记录。在这些患者中，27例（54只眼）被诊断为青光眼，16例（32只眼）无青光眼证据。所有患者均进行了眼前节OCT、前房角镜检查或两者均有。
43例无虹膜患者的平均年龄为32±17岁，27例（62%）为女性。25例（58%）患者记录了眼前节OCT和前房角镜检查，18例（42%）患者仅进行了前房角镜检查。在54只无虹膜合并青光眼的眼中，3例患者（11%）的4只眼（7%）房角部分或完全关闭。在32只无青光眼的眼中，所有眼（100%）房角开放。无虹膜合并青光眼眼的开放房角比例与无青光眼的无虹膜眼相比无显著差异（P=0.32）。在4只房角关闭的眼中，所有眼均有白内障、青光眼和/或角膜病变的既往手术史。与无青光眼的眼相比，开角型青光眼和闭角型青光眼眼的既往手术史比例显著更高（分别为P<0.001和P=0.002）。
大多数无虹膜合并青光眼的眼房角开放，与无青光眼的无虹膜患者相似。所有无虹膜合并青光眼且房角关闭的眼均有眼部手术史。
