Chen Jieying, Tang Guangyu
Department of Radiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Onco Targets Ther. 2019 Aug 8;12:6267-6273. doi: 10.2147/OTT.S212752. eCollection 2019.
Triple-negative breast cancer is associated with a poor prognosis, and effective biomarkers for targeted diagnosis and treatment are lacking. The tumorigenicity of the provirus integration site for Moloney murine leukemia virus 1 () gene has been studied for many years. However, its significance in breast cancer remains unclear. In this review we briefly summarized the physiological characteristics and regulation of PIM-1 kinase, and subsequently focused on the role of PIM-1 in tumors, especially breast cancer. Oncogene was found to be upregulated in breast cancer, especially in triple-negative breast cancer. Moreover, it is involved in tumorigenesis and the development of drug resistance, and linked to poor prognosis. A highly selective probe targeting PIM-1 for imaging has emerged, suggesting that PIM-1 may be a potential biomarker for the accurate diagnosis and targeted therapy of triple-negative breast cancer.
三阴性乳腺癌预后较差，且缺乏用于靶向诊断和治疗的有效生物标志物。莫洛尼鼠白血病病毒1（PIM-1）基因前病毒整合位点的致瘤性已被研究多年。然而，其在乳腺癌中的意义仍不明确。在本综述中，我们简要总结了PIM-1激酶的生理特性和调控，随后重点关注了PIM-1在肿瘤尤其是乳腺癌中的作用。癌基因PIM-1在乳腺癌中尤其是三阴性乳腺癌中被发现上调。此外，它参与肿瘤发生和耐药性发展，并与预后不良相关。一种针对PIM-1的高选择性成像探针已经出现，这表明PIM-1可能是三阴性乳腺癌准确诊断和靶向治疗的潜在生物标志物。
