Department of Biomedical Engineering, Dalian University of Technology, Dalian 116024, China.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
Biomolecules. 2018 Feb 4;8(1):7. doi: 10.3390/biom8010007.
Ovarian cancer is a medical term that includes a number of tumors with different molecular biology, phenotypes, tumor progression, etiology, and even different diagnosis. Some specific treatments are required to address this heterogeneity of ovarian cancer, thus molecular characterization may provide an important tool for this purpose. On a molecular level, proviral-integration site for Moloney-murine leukemia virus (PIM) kinases are over expressed in ovarian cancer and play a vital role in the regulation of different proteins responsible for this tumorigenesis. Likewise, the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is also a central regulator of the ovarian cancer. Interestingly, recent research has linked the PIM kinases to the PI3K/AKT/mTOR pathway in several types of cancers, but their connection in ovarian cancer has not been studied yet. Once the exact relationship of PIM kinases with the PI3K/AKT/mTOR pathway is acquired in ovarian cancer, it will hopefully provide effective treatments on a molecular level. This review mainly focuses on the role of PIM kinases in ovarian cancer and their interactions with proteins involved in its progression. In addition, this review suggests a connection between the PIM kinases and the PI3K/AKT/mTOR pathway and their parallel mechanism in the regulation of ovarian cancer.
卵巢癌是一个医学术语，包括许多具有不同分子生物学、表型、肿瘤进展、病因甚至不同诊断的肿瘤。为了解决卵巢癌的这种异质性，需要一些特定的治疗方法，因此分子特征分析可能为此提供一个重要的工具。在分子水平上，莫洛尼鼠白血病病毒（Moloney-murine leukemia virus，Mo-MLV）前病毒整合位点（Proviral-integration site for Moloney-murine leukemia virus，PIM）激酶在卵巢癌中过度表达，在调节不同的蛋白质方面发挥着重要作用，这些蛋白质与肿瘤发生有关。同样，磷酸肌醇 3-激酶（phosphoinositide 3-kinase，PI3K）/蛋白激酶 B（protein kinase B，AKT）/哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin，mTOR）通路也是卵巢癌的一个重要调节因子。有趣的是，最近的研究将 PIM 激酶与几种类型癌症中的 PI3K/AKT/mTOR 通路联系起来，但它们在卵巢癌中的联系尚未得到研究。一旦在卵巢癌中获得 PIM 激酶与 PI3K/AKT/mTOR 通路的确切关系，有望在分子水平上提供有效的治疗方法。本综述主要关注 PIM 激酶在卵巢癌中的作用及其与参与肿瘤进展的蛋白质的相互作用。此外，本综述还提出了 PIM 激酶与 PI3K/AKT/mTOR 通路之间的联系及其在调节卵巢癌中的平行机制。
