Babaei Mansour, Shamsi Reza, Heidari Behzad, Bijani Ali, Hosseini Seyed Reza
Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Int J Endocrinol Metab. 2019 Jul 9;17(3):e80780. doi: 10.5812/ijem.80780. eCollection 2019 Jul.
Osteoporosis is associated with decreased antioxidant defenses and serum uric acid (UA) as an antioxidant may exert a protective effect on bone mass.
This study aimed to determine the association between serum UA and bone mineral density (BMD) in the elderly population.
All participants of the Amirkola Health and Ageing Project aged ≥ 60 years entered the study. BMD in the femoral neck (FN-BMD) and lumbar spine (LS-BMD) was determined by dual energy X-ray absorptiometry and osteoporosis was defined as BMD T-score < - 2.5 at either FN or LS. The patients were classified according to serum UA levels as < 4; 4 - 4.99; 5 - 5.99; 6 - 6.99 and > 7 mg/dL. In statistical analysis, the value of BMD as well as frequency of osteoporosis in each subgroup were compared with the control group (UA < 4 mg/dL).
A total of 1080 patients were studied. By increasing serum UA from < 4 mg/dL to > 7 mg/dL the BMD at both measurement sites increased as well. The serum UA was associated with decreased risk of osteoporosis. In multivariate analysis, the odds of osteoporosis in the subgroup with serum UA levels between 4 - 4.99 mg/dL was significantly lower than the control group (OR = 0.66, 95% CI, 0.44 - 0.99). Age and female sex were associated with increased odds of osteoporosis (OR = 1.08, 95% CI, 1.05 - 1.10 and OR = 10.62, 95% CI, 7.53 - 14.97 respectively).
These findings indicate a negative association between serum UA and osteoporosis in the elderly population aged ≥ 60 years.
骨质疏松症与抗氧化防御能力下降有关，而血清尿酸（UA）作为一种抗氧化剂可能对骨量发挥保护作用。
本研究旨在确定老年人群血清UA与骨密度（BMD）之间的关联。
纳入年龄≥60岁的阿米科拉健康与衰老项目的所有参与者。采用双能X线吸收法测定股骨颈骨密度（FN-BMD）和腰椎骨密度（LS-BMD），骨质疏松症定义为FN或LS的BMD T值< - 2.5。患者根据血清UA水平分为<4；4 - 4.99；5 - 5.99；6 - 6.99和>7 mg/dL。在统计分析中，将每个亚组的BMD值以及骨质疏松症的发生率与对照组（UA<4 mg/dL）进行比较。
共研究了1080例患者。随着血清UA从<4 mg/dL增加到>7 mg/dL，两个测量部位的BMD也增加。血清UA与骨质疏松症风险降低相关。在多变量分析中，血清UA水平在4 - 4.99 mg/dL亚组中患骨质疏松症的几率显著低于对照组（OR = 0.66，95%CI，0.44 - 0.99）。年龄和女性与骨质疏松症几率增加相关（分别为OR = 1.08，95%CI，1.05 - 1.10和OR = 10.62，95%CI，7.53 - 14.97）。
这些发现表明，在年龄≥60岁的老年人群中，血清UA与骨质疏松症呈负相关。
