Yao Xiaocong, Chen Lin, Xu Huihui, Zhu Zhongxin
Department of Osteoporosis Care and Control, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, China.
Department of Immune and Rheumatology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, China.
Int J Endocrinol. 2020 Jun 29;2020:3082318. doi: 10.1155/2020/3082318. eCollection 2020.
Uric acid has been found to be potentially protective in bone metabolism. We investigated the relationship between serum uric acid (sUA) and lumbar bone mineral density (BMD) among 4156 participants aged 60 years and over from the National Health and Nutrition Examination Survey (NHANES).
To estimate the association between sUA and lumbar BMD, multivariate logistic regression analyses were conducted. Fitted smoothing curves and generalized additive models were also performed.
We found sUA positively correlated with lumbar BMD after adjusting for other confounders. On subgroup analyses, stratified by sex and race/ethnicity, the positive correlation of sUA with lumbar BMD remained in both men and women, as well as in whites and Mexican Americans, but not in blacks. In blacks, the association of sUA with lumbar BMD was an inverted -shaped curve (inflection point: 7.5 mg/dL).
Our study revealed a positive relationship between sUA and lumbar BMD among most old adults. This association followed an inverted -shaped curve among blacks.
已发现尿酸在骨代谢中可能具有保护作用。我们在来自美国国家健康与营养检查调查（NHANES）的4156名60岁及以上参与者中，研究了血清尿酸（sUA）与腰椎骨密度（BMD）之间的关系。
为评估sUA与腰椎BMD之间的关联，进行了多因素逻辑回归分析。还绘制了拟合平滑曲线并建立了广义相加模型。
在调整其他混杂因素后，我们发现sUA与腰椎BMD呈正相关。在按性别和种族/民族分层的亚组分析中，sUA与腰椎BMD的正相关在男性和女性以及白人和墨西哥裔美国人中均存在，但在黑人中不存在。在黑人中，sUA与腰椎BMD的关联呈倒U形曲线（拐点：7.5mg/dL）。
我们的研究揭示了大多数老年人中sUA与腰椎BMD之间存在正相关关系。在黑人中，这种关联呈倒U形曲线。
