Denyer Willis Laurie, Chandler Clare
Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK.
BMJ Glob Health. 2019 Aug 15;4(4):e001590. doi: 10.1136/bmjgh-2019-001590. eCollection 2019.
Antimicrobial resistance (AMR) is a major challenge of our time. A key global objective is to reduce antibiotic use (ABU), in order to reduce resistance caused by antimicrobial pressure. This is often set as a 'behaviour change' issue, locating intervention efforts in the knowledge and attitudes of individual prescribers and users of medicines. Such approaches have had limited impact and fall short of addressing wider drivers of antibiotic use. To address the magnitude of antibiotic overuse requires a wider lens to view our relationships with these medicines. This article draws on ethnographic research from East Africa to answer the question of what roles antibiotics play beyond their immediate curative effects. We carried out interviews, participant observation and documentary analysis over a decade in northeast Tanzania and eastern and central Uganda. Our findings suggest that antibiotics have become a 'quick fix' in our modern societies. They are a in fractured health systems; a at local and global scales, for humans, animals and crops; a in settings of minimised resources; and a in landscapes scarred by political and economic violence. Conceptualising antibiotic use as a 'quick fix' infrastructure shifts attention to the structural dimensions of AMR and antimicrobial use (AMU) and raises our line of sight into the longer term, generating more systemic solutions that have greater chance of achieving equitable impact.
抗菌药物耐药性(AMR)是我们这个时代的一项重大挑战。一个关键的全球目标是减少抗生素使用(ABU),以降低抗菌压力导致的耐药性。这通常被设定为一个“行为改变”问题,将干预措施的重点放在个体开药者和药物使用者的知识和态度上。此类方法的影响有限,未能解决抗生素使用的更广泛驱动因素。要解决抗生素过度使用的问题,需要从更广阔的视角审视我们与这些药物的关系。本文借鉴东非的人种志研究,以回答抗生素除了其直接治疗效果之外还发挥着什么作用的问题。我们在坦桑尼亚东北部以及乌干达东部和中部开展了为期十年的访谈、参与观察和文献分析。我们的研究结果表明,抗生素已成为现代社会中的一种“快速解决方案”。它们是破碎的卫生系统中的一种 ;在地方和全球层面,对人类、动物和作物而言是一种 ;在资源匮乏的环境中是一种 ;在因政治和经济暴力而伤痕累累的环境中是一种 。将抗生素使用概念化为一种“快速解决方案”基础设施,会将注意力转移到AMR和抗菌药物使用(AMU)的结构层面,并将我们的视线延伸到更长远的未来,从而产生更具系统性的解决方案,更有机会实现公平影响。
(注:原文中部分空格处内容缺失,无法准确完整翻译)