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临床癫痫发作开始前头皮脑电图状态的分类。

Classification of Scalp EEG States Prior to Clinical Seizure Onset.

作者信息

Jacobs Daniel, Liu Yuhan H, Hilton Trevor, Del Campo Martin, Carlen Peter L, Bardakjian Berj L

机构信息

1Institute of Biomaterials and Biomedical Engineering, University of TorontoTorontoONM5S 3G9Canada.

2Department of Electrical and Computer EngineeringUniversity of TorontoTorontoONM5S 3G9Canada.

出版信息

IEEE J Transl Eng Health Med. 2019 Aug 16;7:2000203. doi: 10.1109/JTEHM.2019.2926257. eCollection 2019.

DOI:10.1109/JTEHM.2019.2926257
PMID:31497409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6726463/
Abstract

OBJECTIVE

To investigate the feasibility of improving the performance of an EEG-based multistate classifier (MSC) previously proposed by our group.

RESULTS

Using the random forest (RF) classifiers on the previously reported dataset of patients, but with three improvements to classification logic, the specificity of our alarm algorithm improves from 82.4% to 92.0%, and sensitivity from 87.9% to 95.2%.

DISCUSSION

The MSC could be a useful approach for seizure-monitoring both in the clinic and at home.

METHODS

Three improvements to the MSC are described. Firstly, an additional check using RF outputs is made prior to alarm to confirm increasing probability of a seizure onset state. Secondly, a post-alarm detection horizon that accounts for the seizure state duration is implemented. Thirdly, the alarm decision window is kept constant.

摘要

目的

研究改进我们小组之前提出的基于脑电图的多状态分类器(MSC)性能的可行性。

结果

在先前报告的患者数据集上使用随机森林(RF)分类器,但对分类逻辑进行了三项改进,我们的警报算法的特异性从82.4%提高到92.0%,敏感性从87.9%提高到95.2%。

讨论

MSC可能是一种在临床和家庭中进行癫痫发作监测的有用方法。

方法

描述了对MSC的三项改进。首先,在发出警报之前使用RF输出进行额外检查,以确认癫痫发作起始状态的概率增加。其次,实施了一个考虑癫痫发作状态持续时间的警报后检测范围。第三,警报决策窗口保持不变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e76/6726463/d9e8b9c5e0fd/barda1abc-2926257.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e76/6726463/d9e8b9c5e0fd/barda1abc-2926257.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e76/6726463/d9e8b9c5e0fd/barda1abc-2926257.jpg

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本文引用的文献

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2
Seizure detection: do current devices work? And when can they be useful?癫痫发作检测:现有设备是否有效?何时有用?
Curr Neurol Neurosci Rep. 2018 May 23;18(7):40. doi: 10.1007/s11910-018-0849-z.
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Bilateral preictal signature of phase-amplitude coupling in canine epilepsy.
头皮 EEG 中使用带扩张卷积的多尺度神经网络进行儿科癫痫发作预测。
IEEE J Transl Eng Health Med. 2022 Jan 18;10:4900209. doi: 10.1109/JTEHM.2022.3144037. eCollection 2022.
犬癫痫中相位-振幅耦合的双侧发作前期特征
Epilepsy Res. 2018 Jan;139:123-128. doi: 10.1016/j.eplepsyres.2017.11.009. Epub 2017 Nov 26.
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Dynamics of convulsive seizure termination and postictal generalized EEG suppression.惊厥性癫痫发作终止及发作后广泛性脑电图抑制的动力学
Brain. 2017 Mar 1;140(3):655-668. doi: 10.1093/brain/aww322.
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Prediction of antiepileptic drug treatment outcomes using machine learning.使用机器学习预测抗癫痫药物治疗结果
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Epileptogenic Source Imaging Using Cross-Frequency Coupled Signals From Scalp EEG.利用头皮脑电图的交叉频率耦合信号进行癫痫源成像
IEEE Trans Biomed Eng. 2016 Dec;63(12):2607-2618. doi: 10.1109/TBME.2016.2613936.
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Phase-Amplitude Coupling Is Elevated in Deep Sleep and in the Onset Zone of Focal Epileptic Seizures.在深度睡眠和局灶性癫痫发作的起始区域,相位-振幅耦合增强。
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Defining regions of interest using cross-frequency coupling in extratemporal lobe epilepsy patients.利用跨频耦合为颞叶外癫痫患者定义感兴趣区域。
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Measuring phase-amplitude coupling between neuronal oscillations of different frequencies.测量不同频率神经元振荡之间的相位-幅度耦合。
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