Dudzińska-Usarewicz J, Wrzeciono U, Frankiewicz A, Linkowska E, Köhler T, Nuhn P
Lehrstuhl für Organische Chemie der Karol Marcinkowski Medizinischen Akademie, Poznań, VR Polen.
Pharmazie. 1988 Sep;43(9):611-3.
The nucleophilic substitution of hydrogen to synthesize the sulphonyl indazole derivatives 9-16 is described. The structures of the substitution products are discussed using H-NMR spectra. Chemical structural proof was given by steric hindrance observed in the process of chorination of 9-16. The compounds 3, 4, 7, 8, 14, and 16 are studied to find an inhibition on phospholipase-A2 and lipoxygenase-I.
描述了通过氢的亲核取代来合成磺酰基吲唑衍生物9 - 16的过程。使用氢核磁共振光谱讨论了取代产物的结构。通过在9 - 16氯化过程中观察到的空间位阻给出了化学结构证明。对化合物3、4、7、8、14和16进行了研究，以寻找其对磷脂酶 - A2和脂氧合酶 - I的抑制作用。
