Mosti L, Menozzi G, Schenone P, Tortora G, di Mauro G, Lama M, Marmo E
Farmaco Sci. 1987 Apr;42(4):259-66. doi: 10.1002/chin.198744184.
The synthesis of 1-phenyl- and 1-methyl-5-dialkylamino-methyl-1,5,6,7-tetrahydroindazol-4-ones (III) and (IV) by Mannich reaction of the corresponding 1-substituted 1,5,6,7-tetrahydroindazol-4-ones (I) and (II) is described. Some compounds (III) showed a good antiinflammatory and analgesic activity in rats and mice, respectively. Infiltration anesthesia in mice and antiacetylcholine activity in vitro are also reported.
描述了通过相应的1-取代的1,5,6,7-四氢吲唑-4-酮（I）和（II）的曼尼希反应合成1-苯基-和1-甲基-5-二烷基氨基甲基-1,5,6,7-四氢吲唑-4-酮（III）和（IV）。一些化合物（III）分别在大鼠和小鼠中显示出良好的抗炎和镇痛活性。还报道了在小鼠中的浸润麻醉和体外抗乙酰胆碱活性。
