Rolando Monica, Buchrieser Carmen
Biologie des Bactéries Intracellulaires, CNRS UMR 3525, Institut Pasteur, Paris, France.
Front Cell Dev Biol. 2019 Aug 21;7:168. doi: 10.3389/fcell.2019.00168. eCollection 2019.
Bacterial pathogens have developed many different strategies to hijack host cell responses to promote their own survival. The manipulation of lipid biogenesis and cell membrane stability is emerging as a key player in bacterial host cell control. Indeed, many bacterial pathogens such as , or are able to manipulate and use host sphingolipids during multiple steps of the infectious process. Sphingolipids have long been considered only as structural components of cell membranes, however, it is now well known that they are also intracellular and intercellular signaling molecules that play important roles in many eukaryotic cell functions as well as in orchestrating immune responses. Furthermore, they are important to eliminate invading pathogens and play a crucial role in infectious diseases. In this review, we focus on the different strategies employed by pathogenic bacteria to hijack the sphingolipid balance in the host cell to promote cellular colonization.
细菌病原体已经发展出许多不同的策略来劫持宿主细胞反应以促进自身存活。脂质生物合成和细胞膜稳定性的调控正成为细菌控制宿主细胞的关键因素。事实上，许多细菌病原体，如 、 或 ，能够在感染过程的多个步骤中操纵并利用宿主鞘脂。长期以来，鞘脂一直仅被视为细胞膜的结构成分，然而，现在人们已经清楚地知道它们也是细胞内和细胞间的信号分子，在许多真核细胞功能以及协调免疫反应中发挥重要作用。此外，它们对于清除入侵病原体很重要，并且在传染病中起关键作用。在这篇综述中，我们重点关注病原菌采用的不同策略，以劫持宿主细胞中的鞘脂平衡来促进细胞定植。
