Azuma Sanami, Kikuta Shu, Yoshida Masafumi, Ando Mizuo, Kondo Kenji, Yamasoba Tatsuya
Department of Otolaryngology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
Acta Otolaryngol. 2019 Nov;139(11):1030-1037. doi: 10.1080/00016489.2019.1659515. Epub 2019 Sep 9.
A diagnostic indicator for differentiating squamous cell carcinomas (SCCs) from inverted papillomas (IPs) has not been established. This study aimed to evaluate whether CT attenuation values relative to those of the brainstem (relative CT number) could be useful in differentiating IPs from SCCs. Consecutive patients who were pathologically diagnosed with IP or SCC between 2007 and 2017 were retrospectively identified. Relative CT numbers were compared between the two patient groups. The factors with predictive power for differentiating IPs from SCCs were identified by univariate and multivariate logistic regression analyses. Fifty-four sinonasal tumour cases were finally analysed (IP, 25 cases; SCC, 29 cases). Relative CT numbers were significantly higher in SCC than in IP ( < .001). The univariate logistic regression analysis showed BMI, relative CT number, and disease duration to have predictive value for differentiating IPs from SCCs. In the multivariate logistic regression analysis, only the relative CT number had predictive value for distinguishing IP from SCC (odds ratio, 1.97), with a relative CT number of ≥1.4 being significantly associated with SCC. High relative CT numbers could potentially be used to identify SCCs, and their measurement could provide a basis for differentiating IPs from SCCs.
目前尚未建立用于区分鳞状细胞癌（SCC）与内翻性乳头状瘤（IP）的诊断指标。本研究旨在评估相对于脑干的CT衰减值（相对CT数值）是否有助于鉴别IP与SCC。回顾性纳入2007年至2017年间经病理诊断为IP或SCC的连续患者。比较两组患者的相对CT数值。通过单因素和多因素逻辑回归分析确定区分IP与SCC的预测因素。最终分析了54例鼻窦肿瘤病例（IP 25例，SCC 29例）。SCC的相对CT数值显著高于IP（<0.001）。单因素逻辑回归分析显示，体重指数、相对CT数值和病程对区分IP与SCC具有预测价值。在多因素逻辑回归分析中，只有相对CT数值对区分IP与SCC具有预测价值（优势比为1.97），相对CT数值≥1.4与SCC显著相关。较高的相对CT数值可能有助于识别SCC，其测量可为鉴别IP与SCC提供依据。
