Marioni Gino, Brescia Giuseppe, Nicolè Lorenzo, Marchese-Ragona Rosario, Barion Umberto, Giacomelli Luciano, Marino Filippo, Martini Alessandro, Ottaviano Giancarlo
From the 1 Otolaryngology Section, Department of Neurosciences, Padova University, Padova, Italy, and.
2 Department of Medicine, Padova University, Padova, Italy.
Am J Rhinol Allergy. 2018 Mar;32(2):78-81. doi: 10.1177/1945892418762644. Epub 2018 Mar 23.
Sinonasal inverted (schneiderian) papilloma (IP) is histologically benign but shows a propensity for malignant transformation. Survivin, a member of the inhibitor of the apoptosis family of proteins that controls cell division, apoptosis, metastasis, and, probably, also neoangiogenesis, is overexpressed in essentially all human cancers. Overexpression of the multidomain protein cortactin has also been associated with increased cell migration, invasion, and metastatic potential in several malignancies.
The aim of the present study was to preliminarily investigate survivin and cortactin expression in a consecutive series of sinonasal IPs, and IP-associated squamous cell carcinomas (SCC).
Immunohistochemical expression of nuclear survivin and cortactin was measured in 19 consecutive sinonasal IPs and 3 IP-associated SCCs.
The mean ± standard deviation nuclear survivin expression was 9.4 ± 9.2% and 31.7% ± 15.4% in sinonasal IPs and SCCs, respectively (p < 0.0001). Results of cortactin immunostaining was strongly positive in the cytoplasm of both sinonasal IPs and SCCs: no significant difference emerged between the IP and SCC epithelial components.
Nuclear survivin expression was significantly higher in SCCs than in IPs. Prospective, multi-institutional prognostic studies, preferably on an international scale (given the few cases treated at single institutions), are needed to confirm the role of survivin in IP malignant transformation.
鼻窦内翻性（施奈德氏）乳头状瘤（IP）在组织学上是良性的，但有恶变倾向。生存素是一种控制细胞分裂、凋亡、转移以及可能还有新生血管生成的凋亡抑制蛋白家族成员，在基本上所有人类癌症中均过度表达。多结构域蛋白皮质肌动蛋白的过度表达也与几种恶性肿瘤中细胞迁移、侵袭及转移潜能增加有关。
本研究的目的是初步调查一系列连续的鼻窦IP以及IP相关的鳞状细胞癌（SCC）中生存素和皮质肌动蛋白的表达情况。
对19例连续的鼻窦IP和3例IP相关的SCC进行核生存素和皮质肌动蛋白的免疫组化表达检测。
鼻窦IP和SCC中核生存素的平均±标准差表达分别为9.4±9.2%和31.7%±15.4%（p<0.0001）。皮质肌动蛋白免疫染色结果在鼻窦IP和SCC的细胞质中均呈强阳性：IP和SCC的上皮成分之间未出现显著差异。
SCC中的核生存素表达显著高于IP。需要进行前瞻性、多机构的预后研究，最好是在国际范围内（鉴于单个机构治疗的病例较少），以证实生存素在IP恶变中的作用。
