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化学套装化学品:对其潜在毒性的评估。

Chemistry set chemicals: an evaluation of their toxic potential.

作者信息

Everson G W, Normann S A, Casey J P

机构信息

Louisiana Regional Poison Center, LSU Medical Center, Shreveport 71130.

出版信息

Vet Hum Toxicol. 1988 Dec;30(6):589-92.

PMID:3149815
Abstract

KM, a 14-year-old female packed 3 empty Sudafed SA capsules with 3 parts sodium chloride and 1 part cobalt chloride obtained from her brother's chemistry set. Following this, she ingested all 3 capsules. While the child had an uneventful hospital course, cobalt serum levels drawn 12 and 22 hr post-ingestion were measured at 7.8 micrograms/dL and 0.7 micrograms/dL, respectively. Due to the limited amount of data on the toxicity of cobalt chloride and the nature of the exposure, the case prompted a review of the potential toxicity of chemistry set chemicals available to consumers. The contents of 3 chemistry sets were evaluated. Each contained either 28, 14, or 9 chemicals. A total of 38 different chemicals were weighted and evaluated to determine whether the amount contained represented a potentially toxic or lethal dose to a 2-year-old, 12 kg child. Fifty-three percent of the chemicals evaluated contained quantities sufficient to result in toxicity. Thirteen percent of chemicals contained potentially lethal quantities, while 18% were considered non-toxic. Sixteen percent of the chemicals could not be evaluated due to lack of data in the literature. Only one chemistry set utilized child resistant closures. However, 65% of all potentially toxic chemicals and 100% of potentially lethal chemicals had appropriate first aid instructions.

摘要

KM是一名14岁女性,她用从哥哥的化学套件中获取的3份氯化钠和1份氯化钴填充了3颗空的速达菲SA胶囊。之后,她吞下了所有3颗胶囊。尽管该患儿在医院的病程平稳,但摄入后12小时和22小时检测的钴血清水平分别为7.8微克/分升和0.7微克/分升。由于关于氯化钴毒性的数据有限以及此次暴露的性质,该病例促使人们对消费者可获得的化学套件化学品的潜在毒性进行了审查。对3套化学套件的内容物进行了评估。每套分别含有28种、14种或9种化学品。总共对38种不同的化学品进行了称重和评估,以确定所含数量对一名12公斤重的2岁儿童是否构成潜在毒性或致死剂量。所评估的化学品中有53%所含数量足以导致中毒。13%的化学品含有潜在致死量,而18%被认为无毒。由于文献中缺乏数据,16%的化学品无法评估。只有一套化学套件使用了儿童安全盖。然而,所有潜在有毒化学品中有65%以及所有潜在致命化学品中有100%都有适当的急救说明。

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