Department of Biomedical Engineering, University of Minnesota, 312 Church St. SE, 7-105 Nils Hasselmo Hall, Minneapolis, Minnesota 55455, USA.
Soft Matter. 2019 Sep 18;15(36):7122-7126. doi: 10.1039/c9sm01314h.
Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.
这里将生物分子识别的定向性区分用作调控纳米粒子自组装或稳定性的分子工程工具。纳米粒子与异二聚化的螺旋线圈 A 和 B 缀合，这些螺旋线圈以平行取向结合。只需翻转一个螺旋线圈的取向，就可以得到自组装或胶体稳定的纳米粒子。
