金纳米颗粒与DNA共轭物的制备、表征及操作
Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA.
作者信息
Eidelshtein Gennady, Fattal Moran, Avishai Gavriel, Kempinski Benjamin, Giannini Clelia, Kotlyar Alexander
机构信息
Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences and the Center of Nanoscience and Nanotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.
Department of Chemistry, University of Milan, via Golgi 19, 20133 Milan, Italy.
出版信息
Nanomaterials (Basel). 2016 Sep 8;6(9):167. doi: 10.3390/nano6090167.
Here we described the preparation and characterization by atomic force microscopy of dumbbell-shaped conjugates between 450 bp double-stranded DNA polymer, poly(dG)-poly(dC), and 5 nm gold nanoparticles (GNPs). We have demonstrated that the size of the nanoparticles in the conjugates can be increased in a controlled fashion. Application of the conjugates for measuring the electrical conductivity of DNA is discussed.
在此，我们描述了450碱基对双链DNA聚合物聚（dG）-聚（dC）与5纳米金纳米颗粒（GNP）之间哑铃形缀合物的制备及其原子力显微镜表征。我们已经证明，缀合物中纳米颗粒的尺寸可以以可控方式增大。还讨论了该缀合物在测量DNA电导率方面的应用。
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