Huang Leyi, Zhou Yinli, Xiao Hui, Li Yajia, Zhou Zhiru, Xiao Ziyi, Tong Yixuan, Hu Kun, Kuang Yehong, Shen Minxue, Xiao Yi, Chen Xiang
Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Hunan Engineering Research Center of Skin Health and Disease, Changsha, 410008, China.
Clin Rev Allergy Immunol. 2025 Mar 23;68(1):33. doi: 10.1007/s12016-025-09043-4.
Industrialization and modernization have changed the environment. A group of emerging contaminants (ECs) has been defined recently. Psoriasis, whose incidence has increased in recent years, is a relapsing immune-mediated disease carrying a heavy disease burden. The erythematous scaly plaque is a typical symptom and occurs on several parts of the body. In addition, psoriasis has many comorbidities, such as psoriatic arthritis, diabetes, and depression, damaging the quality of life of patients. IL-17, IL-12, IL-23, and TNF-alpha are important related cytokines. ECs can influence psoriasis through the immune system and inflammatory responses. Specific mechanisms include increasing pro-inflammatory cytokines such as TNF-α and IL-17, and activating immune cells such as macrophages. And for psoriasis patients, it is suggested to reduce the exposure of most ECs. However, the complex mechanisms involved have not been discussed together and concluded. In this review, we summarize the relationship between ECs and psoriasis, focusing on the immune system, especially the immune cells and cytokines. These results can help guide clinical treatment and long-term management of psoriasis.
工业化和现代化改变了环境。近年来，一类新兴污染物（ECs）被定义出来。银屑病是一种复发的免疫介导性疾病，疾病负担沉重，其发病率近年来有所上升。红斑鳞屑斑块是典型症状，可出现在身体的多个部位。此外，银屑病还有许多合并症，如银屑病关节炎、糖尿病和抑郁症，损害患者的生活质量。白细胞介素-17（IL-17）、白细胞介素-12（IL-12）、白细胞介素-23（IL-23）和肿瘤坏死因子-α（TNF-α）是重要的相关细胞因子。新兴污染物可通过免疫系统和炎症反应影响银屑病。具体机制包括增加促炎细胞因子如肿瘤坏死因子-α和白细胞介素-17，以及激活免疫细胞如巨噬细胞。对于银屑病患者，建议减少大多数新兴污染物的暴露。然而，其中涉及的复杂机制尚未被共同讨论和总结。在本综述中，我们总结了新兴污染物与银屑病之间的关系，重点关注免疫系统，尤其是免疫细胞和细胞因子。这些结果有助于指导银屑病的临床治疗和长期管理。
