用于药物递送和细胞成像的具有双模式发光的多功能NaLnF@MOF-Ln纳米复合材料
Multifunctional NaLnF@MOF-Ln Nanocomposites with Dual-Mode Luminescence for Drug Delivery and Cell Imaging.
作者信息
Wang Dan, Zhao Chen, Gao Guoyang, Xu Linna, Wang Guofeng, Zhu Peifen
机构信息
Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China.
Department of Physics and Engineering Physics, The University of Tulsa, Tulsa, OK 74104, USA.
出版信息
Nanomaterials (Basel). 2019 Sep 6;9(9):1274. doi: 10.3390/nano9091274.
Multifunctional nanomaterials for bioprobe and drug carrier have drawn great attention for their applications in the early monitoring the progression and treatment of cancers. In this work, we have developed new multifunctional water-soluble NaLnF@MOF-Ln nanocomposites with dual-mode luminescence, which is based on stokes luminescent mesoporous lanthanide metal-organic frameworks (MOFs-Y:Eu) and anti-stokes luminescent NaYF:Tm/Yb nanoparticles. The fluorescence mechanism and dynamics are investigated and the applications of these nanocomposites as bioprobes and drug carriers in the cancer imaging and treatment are explored. Our results demonstrate that these nanocomposites with the excellent two-color emission show great potential in drug delivery, cancer cell imaging, and treatment, which are attributed to the unique spatial structure and good biocompatibility characteristics of NaLnF@MOF-Ln nanocomposites.
用于生物探针和药物载体的多功能纳米材料因其在癌症早期进展监测和治疗中的应用而备受关注。在这项工作中，我们基于斯托克斯发光介孔镧系金属有机框架（MOFs-Y:Eu）和反斯托克斯发光的NaYF:Tm/Yb纳米粒子，开发了具有双模发光的新型多功能水溶性NaLnF@MOF-Ln纳米复合材料。研究了其荧光机制和动力学，并探索了这些纳米复合材料作为生物探针和药物载体在癌症成像和治疗中的应用。我们的结果表明，这些具有出色双色发射的纳米复合材料在药物递送、癌细胞成像和治疗方面具有巨大潜力，这归因于NaLnF@MOF-Ln纳米复合材料独特的空间结构和良好的生物相容性特性。
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