Trofimov Alexey D, Ivanova Anna A, Zyuzin Mikhail V, Timin Alexander S
Department of Nanophotonics and Metamaterials, Saint Petersburg National Research University of Information Technologies, ITMO University, 197101 St. Petersburg, Russia.
Research School of Chemical and Biomedical Engineering, National Research Tomsk Polytechnic University, Lenin Avenue 30, 634050 Tomsk, Russia.
Pharmaceutics. 2018 Sep 25;10(4):167. doi: 10.3390/pharmaceutics10040167.
Porous inorganic nanostructured materials are widely used nowadays as drug delivery carriers due to their adventurous features: suitable architecture, large surface area and stability in the biological fluids. Among the different types of inorganic porous materials, silica, calcium carbonate, and calcium phosphate have received significant attention in the last decade. The use of porous inorganic materials as drug carriers for cancer therapy, gene delivery etc. has the potential to improve the life expectancy of the patients affected by the disease. The main goal of this review is to provide general information on the current state of the art of synthesis of the inorganic porous particles based on silica, calcium carbonate and calcium phosphate. Special focus is dedicated to the loading capacity, controllable release of drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic field, and ultrasound). Moreover, the diverse compounds to deliver with silica, calcium carbonate and calcium phosphate particles, ranging from the commercial drugs to genetic materials are also discussed.
合适的结构、大的表面积以及在生物流体中的稳定性，如今被广泛用作药物递送载体。在不同类型的无机多孔材料中，二氧化硅、碳酸钙和磷酸钙在过去十年中受到了广泛关注。将多孔无机材料用作癌症治疗、基因递送等的药物载体，有可能提高受该疾病影响患者的预期寿命。本综述的主要目的是提供基于二氧化硅、碳酸钙和磷酸钙的无机多孔颗粒合成的当前技术水平的一般信息。特别关注负载能力、在内部生物刺激（如pH值、氧化还原、酶）和外部非侵入性刺激（如光、磁场和超声）下药物的可控释放。此外，还讨论了用二氧化硅、碳酸钙和磷酸钙颗粒递送的各种化合物，从商业药物到遗传物质。
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