State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , PR China.
University of Science and Technology of China , Hefei , PR China.
J Biomater Sci Polym Ed. 2019 Dec;30(17):1670-1685. doi: 10.1080/09205063.2019.1657621. Epub 2019 Sep 10.
Polyethylene glycol (PEG) with one and two ends are grafted onto poly(styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS) via polydopamine (PDA) as a spacer to fabricate a hemocompatible surface. Linear and looped conformational PEGs modified SEBS are obtained, and the structures and compositions are confirmed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The hemocompatibility of SEBS are improved by the modification of PDA and PEG, and the proteins resistances of the looped PEG are superior to that of the linear PEG with the same grafting length and mass. Quartz crystal microbalance with dissipation illustrates that the protein resistance mechanism of looped PEG is because of the huge viscoelasticity and deformation. Furthermore, looped and linear PEGs with the same grafting density are grafted onto SEBS surface to clarify the superiority of the looped conformation. Protein adsorption of looped PEG with twice length of linear PEG shows lower adsorbed amount than the others. Therefore, immobilizing the looped conformation of PEG on SEBS surface is a versatile and efficient way to improve the hemocompatibility of SEBS.
通过聚多巴胺（PDA）作为间隔物，将一端和两端的聚乙二醇（PEG）接枝到苯乙烯-丁二烯-苯乙烯（SEBS）上，制备出具有良好血液相容性的表面。通过衰减全反射傅里叶变换红外光谱（ATR-FTIR）和 X 射线光电子能谱（XPS）确认了线性和环型 PEG 修饰的 SEBS 的结构和组成。通过 PDA 和 PEG 的修饰，提高了 SEBS 的血液相容性，并且具有相同接枝长度和质量的环型 PEG 的蛋白质抵抗性优于线性 PEG。石英晶体微天平（QCM-D）表明，环型 PEG 的蛋白质抵抗机制是由于其巨大的粘弹性和变形。此外，将具有相同接枝密度的环型和线性 PEG 接枝到 SEBS 表面，以阐明环型构象的优越性。两倍长度的线性 PEG 的环型 PEG 的蛋白吸附量低于其他 PEG。因此，将 PEG 的环型构象固定在 SEBS 表面是一种提高 SEBS 血液相容性的通用且有效的方法。
