Tsai Bin-Hong, Lin Tse-An, Cheng Chi-Hui, Lin Jui-Che
Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.
Department of Pediatrics, College of Medicine, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Polymers (Basel). 2021 Jan 12;13(2):235. doi: 10.3390/polym13020235.
Styrenic thermoplastic elastomers (TPEs) consist of styrenic blocks. They are connected with other soft segments by a covalent linkage and are widely used in human life. However, in biomedical applications, TPEs need to be chemically hydrogenated in advance to enhance their properties such as strong UV/ozone resistance and thermal-oxidative stability. In this study, films composed of sulfonated hydrogenated TPEs were evaluated. Hydrogenated -butyl styrene-styrene-isoprene block copolymers were synthesized and selectively sulfonated to different degrees by reaction with acetyl sulfate. By controlling the ratio of the hydrogenated -butyl styrene-styrene-isoprene block copolymer and acetyl sulfate, sulfonated films were optimized to demonstrate sufficient mechanical integrity in water as well as good biocompatibility. The thermal plastic sulfonated films were found to be free of cytotoxicity and platelet-compatible and could be potential candidates in biomedical film applications such as wound dressings.
苯乙烯类热塑性弹性体（TPEs）由苯乙烯类嵌段组成。它们通过共价键与其他软链段相连，在人类生活中广泛应用。然而，在生物医学应用中，TPEs需要预先进行化学氢化处理，以增强其诸如强抗紫外线/臭氧性能和热氧化稳定性等性能。在本研究中，对由磺化氢化TPEs组成的薄膜进行了评估。合成了氢化丁基苯乙烯-苯乙烯-异戊二烯嵌段共聚物，并通过与乙酰硫酸反应将其选择性地磺化至不同程度。通过控制氢化丁基苯乙烯-苯乙烯-异戊二烯嵌段共聚物与乙酰硫酸的比例，对磺化薄膜进行了优化，以使其在水中表现出足够的机械完整性以及良好的生物相容性。发现热塑性磺化薄膜无细胞毒性且与血小板相容，可能成为伤口敷料等生物医学薄膜应用的潜在候选材料。
