State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China.
Colloids Surf B Biointerfaces. 2012 May 1;93:127-34. doi: 10.1016/j.colsurfb.2011.12.027. Epub 2012 Jan 2.
Poly(N-vinyl pyrrolidone) (PNVP) was covalently grafted onto the surface of biomedical poly(styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS) elastomer via a technique of UV-induced graft polymerization combined with plasma pre-treatment. The surface graft polymerization of N-vinyl pyrrolidone (NVP) was confirmed by ATR-FTIR and XPS. Effect of the parameters of graft polymerization, i.e., the initiator concentration, the UV irradiation time and the monomer concentration on the grafting density was investigated. The morphology and the wettability of the PNVP-modified surfaces were characterized by AFM and DSA, respectively. Protein adsorption and platelet adhesion were obviously suppressed after PNVP was grafted onto the SEBS substrates.
通过紫外光引发接枝聚合与等离子体预处理相结合的技术，将聚（N-乙烯基吡咯烷酮）（PNVP）共价接枝到生物医学用聚（苯乙烯-嵌段-乙烯-丁烯-嵌段-苯乙烯）（SEBS）弹性体的表面上。ATR-FTIR 和 XPS 证实了 N-乙烯基吡咯烷酮（NVP）的表面接枝聚合。研究了接枝聚合参数，即引发剂浓度、紫外辐照时间和单体浓度对接枝密度的影响。通过 AFM 和 DSA 分别对 PNVP 修饰表面的形貌和润湿性进行了表征。将 PNVP 接枝到 SEBS 基底上后，明显抑制了蛋白质吸附和血小板黏附。
