Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, United Kingdom; email:
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom; email:
Annu Rev Microbiol. 2019 Sep 8;73:133-154. doi: 10.1146/annurev-micro-020518-115617.
Trypanosomes have complex life cycles within which there are both proliferative and differentiation cell divisions. The coordination of the cell cycle to achieve these different divisions is critical for the parasite to infect both host and vector. From studying the regulation of the proliferative cell cycle of the procyclic life cycle stage, three subcycles emerge that control the duplication and segregation of () the nucleus, () the kinetoplast, and () a set of cytoskeletal structures. We discuss how the clear dependency relationships within these subcycles, and the potential for cross talk between them, are likely required for overall cell cycle coordination. Finally, we look at the implications this interdependence has for proliferative and differentiation divisions through the life cycle and in related parasitic trypanosomatid species.
锥虫在其复杂的生活史中有增殖和分化分裂，这两种分裂都需要细胞周期的协调，这对于寄生虫感染宿主和媒介至关重要。通过研究前鞭毛体阶段增殖细胞周期的调控，出现了三个亚周期，控制着()核、()动基体和()一组细胞骨架结构的复制和分离。我们讨论了这些亚周期内明显的依赖关系，以及它们之间潜在的串扰，这对于整体细胞周期的协调是很可能需要的。最后，我们通过生活史和相关寄生原生动物来看这种相互依存性对增殖和分化分裂的影响。
