健康成年人单次输注 1500 毫克后，达巴万星的上皮衬液和血浆浓度。
Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion.
机构信息
Allergan plc, Madison, New Jersey, USA
Allergan plc, Madison, New Jersey, USA.
出版信息
Antimicrob Agents Chemother. 2019 Oct 22;63(11). doi: 10.1128/AAC.01024-19. Print 2019 Nov.
Abstract
Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of dalbavancin into ELF was 36%. ELF levels of dalbavancin exceeded the MICs of and for ≥7 days.
摘要
达巴万星是一种具有长半衰期的糖肽类抗生素。一项 1 期研究采用支气管上皮衬液（ELF）支气管微取样技术，评估了 35 例健康成年人在接受 1500mg 达巴万星后 168 小时内的 ELF 中达巴万星的水平。达巴万星渗透进入 ELF 的程度为 36%。ELF 中达巴万星的浓度超过了 和 的 MIC 值，时间均≥7 天。
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