Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Department of Vascular Biology and Hypertension, University of Alabama at Birmingham, Birmingham, AL, USA.
Adv Exp Med Biol. 2019;1159:109-138. doi: 10.1007/978-3-030-21162-2_7.
Despite the advancements in modern medicine, there are still difficulties in diagnosing common illnesses. The invasiveness and price of the tests used to follow up certain diseases can be a barrier to proper patient follow-up. Sphingolipids are a diverse category of lipids. They are structural molecules in cell membranes and signaling molecules involved in the regulation of crucial cell functions, including cell growth, differentiation, proliferation and apoptosis. Recent research has shown that abnormal sphingolipid metabolism is associated with genetic and metabolic disease processes. Given their crucial role to maintain homeostasis within the body, sphingolipids have been investigated as potential biomarkers to predict disease in the population. Here we discuss how sphingolipids levels are altered in different diseases, thus illustrating their possible use as diagnostic and prognostic biomarkers for disease.
尽管现代医学取得了进步，但仍有一些常见疾病难以诊断。某些疾病的随访检测具有侵入性且费用昂贵，这可能成为患者得到适当随访的障碍。神经鞘脂是一类多样化的脂质。它们是细胞膜的结构分子，也是参与调节关键细胞功能的信号分子，包括细胞生长、分化、增殖和凋亡。最近的研究表明，神经鞘脂代谢异常与遗传和代谢性疾病过程有关。鉴于其在维持体内平衡方面的关键作用，神经鞘脂已被作为预测人群疾病的潜在生物标志物进行研究。在这里，我们讨论了神经鞘脂水平在不同疾病中的变化，从而说明了它们作为疾病诊断和预后生物标志物的可能用途。
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