Awad Gaëlle, Roeckel Laurie-Anne, Massotte Dominique, Olmstead Mary C, Befort Katia
Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Centre de la Recherche Nationale Scientifique, Université de Strasbourg Faculté de Psychologie.
Centre de la Recherche Nationale Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives (INCI), Strasbourg, France.
Behav Pharmacol. 2020 Apr;31(2&3):249-255. doi: 10.1097/FBP.0000000000000496.
Binge eating in humans is driven by hedonic properties of food, suggesting that brain reward systems may contribute to this behaviour. We examined the role of mu opioid receptors (MOP) in binge eating by examining sweet solution intake in mice with genetic deletion of the MOP. Wildtype and MOP knockout mice had 4 hours access to food in the home cage combined with limited (4 hours) access to sucrose (17.1% w/v) or saccharin (0.09% w/v), or continuous (24 hours) access to sucrose. Only limited access groups exhibited binge intake, measured as increased solution consumption during the first hour. Knockout mice consumed less solution and food during the first hour as well as less food each day compared with wildtype mice. Limited access groups consumed more food and gained more weight than continuous access groups, and the effect was magnified in saccharin-consuming mice. Indeed, the increased food consumption in animals given limited access to saccharin was so excessive that caloric intake of this group was significantly higher than either of the sucrose groups (limited or continuous access). Within this group, females consumed more food per bodyweight than males, highlighting important sex differences in feeding behaviours under restricted access schedules.
人类的暴饮暴食受食物享乐特性驱动，这表明大脑奖赏系统可能促成了这种行为。我们通过检测MOP基因敲除小鼠对甜味溶液的摄取情况，研究了μ阿片受体（MOP）在暴饮暴食中的作用。野生型和MOP基因敲除小鼠在饲养笼中可进食4小时，同时对蔗糖（17.1% w/v）或糖精（0.09% w/v）的摄取有限（4小时），或可连续（24小时）摄取蔗糖。只有摄取受限组出现了暴饮暴食，以第一小时内溶液消耗量增加来衡量。与野生型小鼠相比，基因敲除小鼠在第一小时内消耗的溶液和食物较少，且每天消耗的食物也较少。摄取受限组比连续摄取组消耗更多食物且体重增加更多，在摄取糖精的小鼠中这种效应更为明显。实际上，摄取糖精受限的动物食物消耗量增加得非常多，以至于该组的热量摄入量显著高于蔗糖组（摄取受限或连续摄取）中的任何一组。在该组中，雌性小鼠每体重单位消耗的食物比雄性小鼠多，这突出了在受限摄取方案下进食行为中重要的性别差异。
