aDepartment of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University bDepartment of General Physiology, Saint Petersburg State University cInstitute of Translational Biomedicine and Saint Petersburg University Hospital, Saint Petersburg State University, St Petersburg, Russia.
Neuroreport. 2019 Oct 16;30(15):1004-1007. doi: 10.1097/WNR.0000000000001313.
The trace amine-associated receptor 1 (TAAR1) agonist RO5263397 effect on sensory gating in C57BL/6 mice was studied. Sensory gating is a mechanism for dosing and filtering the incoming information, by which the brain regulates the responses to sensory stimuli coming from the environment. Sensory gating deficit is considered to be one of the schizophrenia endophenotypes. TAAR1 agonist at a 1 mg/kg dosage contributed to the sensory gating index (S1-S2) increase. Sensory gating index rose due to the N40 amplitude increase in response to the first stimulus in a pair, whereas the amplitude of the second stimulus remained unchanged. These results suggest that the sensory gating in mice may be modulated through TAAR1-dependent processes, indicating potential contribution of TAAR1 and trace amines in general to the neuropharmacology of cognitive processes.
研究了痕量胺相关受体 1（TAAR1）激动剂 RO5263397 对 C57BL/6 小鼠感觉门控的影响。感觉门控是一种调节大脑对外界环境传入信息反应的机制，通过该机制大脑可以调节对感觉刺激的反应。感觉门控缺陷被认为是精神分裂症的一种表型。1 毫克/千克剂量的 TAAR1 激动剂有助于增加感觉门控指数（S1-S2）。感觉门控指数的升高是由于对一对刺激中的第一个刺激的 N40 振幅增加，而第二个刺激的振幅保持不变。这些结果表明，小鼠的感觉门控可能通过 TAAR1 依赖的过程进行调节，表明 TAAR1 和痕量胺一般对认知过程的神经药理学有潜在贡献。
