Christchurch Health and Development Study, Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Addiction. 2020 Feb;115(2):279-290. doi: 10.1111/add.14814. Epub 2019 Nov 1.
Little is known about how cannabis use over the life-course relates to harms in adulthood. The present study aimed to identify trajectories of cannabis use from adolescence to adulthood and examine both the predictors of these trajectories and adverse adult outcomes associated with those trajectories.
A latent trajectory analysis of a longitudinal birth cohort (from birth to age 35 years).
General community sample (n = 1065) from New Zealand.
Annual frequency of cannabis use (ages 15-35 years); childhood family and individual characteristics (birth to age 16 years); measures of adult outcomes (substance use disorders, ages 30-35 years; mental health disorders, ages 30-35 years; socio-economic outcomes at age 35 years; social/family outcomes at age 35 years).
A six-class solution was the best fit to the data. Individuals assigned to trajectories with higher levels of cannabis use were more likely to have experienced adverse childhood family and individual circumstances. Membership of trajectories with higher levels of use was associated with increased risk of adverse outcomes at ages 30-35 years. Adjustment of these associations for the childhood family and individual predictors largely did not reduce the magnitude of the associations.
In New Zealand, long-term frequent cannabis use, or transition to such use, appears to be robustly associated with diverse harms in adulthood.
关于一生中使用大麻与成年期伤害之间的关系，人们知之甚少。本研究旨在确定从青春期到成年期的大麻使用轨迹，并检验这些轨迹的预测因素以及与这些轨迹相关的不良成年后果。
对新西兰一个纵向出生队列（从出生到 35 岁）进行潜在轨迹分析。
一般社区样本（n=1065）。
大麻使用的年度频率（15-35 岁）；儿童时期家庭和个体特征（出生至 16 岁）；成年后果的测量（30-35 岁的物质使用障碍；30-35 岁的精神健康障碍；35 岁时的社会经济结果；35 岁时的社会/家庭结果）。
六类解决方案最适合数据。被分配到大麻使用水平较高轨迹的个体更有可能经历过不良的儿童时期家庭和个人环境。较高使用水平轨迹的成员与 30-35 岁时不良后果的风险增加有关。对这些关联进行调整，以适应儿童时期的家庭和个体预测因素，在很大程度上并没有降低关联的幅度。
在新西兰，长期频繁使用大麻或过渡到这种使用，似乎与成年期的多种伤害密切相关。
