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TMA (trimethylamine), but not its oxide TMAO (trimethylamine-oxide), exerts haemodynamic effects: implications for interpretation of cardiovascular actions of gut microbiome.

作者信息

Jaworska Kinga, Bielinska Klaudia, Gawrys-Kopczynska Marta, Ufnal Marcin

机构信息

Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1B, Warsaw, Poland.

出版信息

Cardiovasc Res. 2019 Dec 1;115(14):1948-1949. doi: 10.1093/cvr/cvz231.

DOI:10.1093/cvr/cvz231
PMID:31504256
Abstract
摘要

相似文献

1
TMA (trimethylamine), but not its oxide TMAO (trimethylamine-oxide), exerts haemodynamic effects: implications for interpretation of cardiovascular actions of gut microbiome.三甲胺（TMA）而非其氧化物氧化三甲胺（TMAO）具有血流动力学效应：这对解读肠道微生物群的心血管作用具有启示意义。
Cardiovasc Res. 2019 Dec 1;115(14):1948-1949. doi: 10.1093/cvr/cvz231.
2
Trimethylamine But Not Trimethylamine Oxide Increases With Age in Rat Plasma and Affects Smooth Muscle Cells Viability.三甲胺而非氧化三甲胺随年龄在大鼠血浆中增加，并影响平滑肌细胞活力。
J Gerontol A Biol Sci Med Sci. 2020 Jun 18;75(7):1276-1283. doi: 10.1093/gerona/glz181.
3
Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases.三甲胺/氧化三甲胺：饮食与心血管疾病之间的关键因素
Cardiovasc Toxicol. 2021 Aug;21(8):593-604. doi: 10.1007/s12012-021-09656-z. Epub 2021 May 18.
4
High salt intake increases plasma trimethylamine N-oxide (TMAO) concentration and produces gut dysbiosis in rats.高盐摄入会增加血浆三甲胺 N-氧化物（TMAO）的浓度，并在大鼠中产生肠道菌群失调。
Nutrition. 2018 Oct;54:33-39. doi: 10.1016/j.nut.2018.03.004. Epub 2018 Mar 22.
5
Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease.三甲胺和三甲胺 N-氧化物，一种由含黄素单加氧酶 3（FMO3）介导的、与健康和疾病相关的宿主-微生物群代谢轴。
Drug Metab Dispos. 2016 Nov;44(11):1839-1850. doi: 10.1124/dmd.116.070615. Epub 2016 May 17.
6
Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide.肠道微生物群组成可调节饮食中胆碱的生物利用度以及促动脉粥样硬化代谢物氧化三甲胺的积累。
mBio. 2015 Mar 17;6(2):e02481. doi: 10.1128/mBio.02481-14.
7
Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota.白藜芦醇通过重塑肠道微生物群调节氧化三甲胺（TMAO）合成和胆汁酸代谢，减轻TMAO诱导的动脉粥样硬化。
mBio. 2016 Apr 5;7(2):e02210-15. doi: 10.1128/mBio.02210-15.
8
Trimethylamine N-Oxide and Risk of Cardiovascular Disease and Mortality.三甲胺 N-氧化物与心血管疾病风险和死亡率。
Curr Nutr Rep. 2018 Dec;7(4):207-213. doi: 10.1007/s13668-018-0252-z.
9
Heart Failure Disturbs Gut-Blood Barrier and Increases Plasma Trimethylamine, a Toxic Bacterial Metabolite.心力衰竭扰乱肠道-血液屏障并增加血浆三甲胺，一种有毒的细菌代谢物。
Int J Mol Sci. 2020 Aug 26;21(17):6161. doi: 10.3390/ijms21176161.
10
TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats.氧化三甲胺（TMAO）是一种源自海鲜的分子，可促进心力衰竭大鼠的利尿并降低其死亡率。
Elife. 2020 Jun 8;9:e57028. doi: 10.7554/eLife.57028.

引用本文的文献

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Development and Validation of a Simple and Cost-Effective LC-MS/MS Method for the Quantitation of the Gut-Derived Metabolite Trimethylamine N-Oxide in Human Plasma of Healthy and Hyperlipidemic Volunteers.一种用于定量健康和高脂血症志愿者人血浆中肠道衍生代谢物氧化三甲胺的简单且经济高效的液相色谱-串联质谱法的开发与验证
Molecules. 2025 May 30;30(11):2398. doi: 10.3390/molecules30112398.
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TMAO and diabetes: from the gut feeling to the heart of the problem.氧化三甲胺与糖尿病：从直觉到问题的核心
Nutr Diabetes. 2025 May 20;15(1):21. doi: 10.1038/s41387-025-00377-8.
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Microbiome-Derived Trimethylamine N-Oxide (TMAO) as a Multifaceted Biomarker in Cardiovascular Disease: Challenges and Opportunities.
微生物群衍生的氧化三甲胺（TMAO）作为心血管疾病中的多面生物标志物：挑战与机遇
Int J Mol Sci. 2024 Nov 21;25(23):12511. doi: 10.3390/ijms252312511.
4
Spontaneously hypertensive rats exhibit increased liver flavin monooxygenase expression and elevated plasma TMAO levels compared to normotensive and Ang II-dependent hypertensive rats.与正常血压大鼠和血管紧张素II依赖性高血压大鼠相比，自发性高血压大鼠的肝脏黄素单加氧酶表达增加，血浆氧化三甲胺水平升高。
Front Physiol. 2024 Apr 12;15:1340166. doi: 10.3389/fphys.2024.1340166. eCollection 2024.
5
Mice, rats, and guinea pigs differ in FMOs expression and tissue concentration of TMAO, a gut bacteria-derived biomarker of cardiovascular and metabolic diseases.在 FMOs 表达和 TMAO（一种源自肠道细菌的心血管和代谢疾病生物标志物）的组织浓度方面，小鼠、大鼠和豚鼠存在差异。
PLoS One. 2024 Jan 24;19(1):e0297474. doi: 10.1371/journal.pone.0297474. eCollection 2024.
6
Dietary Patterns, Gut Microbiota Remodeling, and Cardiometabolic Disease.饮食模式、肠道微生物群重塑与心血管代谢疾病
Metabolites. 2023 Jun 17;13(6):760. doi: 10.3390/metabo13060760.
7
Impact of Caloric Restriction and Exercise on Trimethylamine N-Oxide Metabolism in Women with Obesity.热量限制和运动对肥胖女性中三甲胺 N-氧化物代谢的影响。
Nutrients. 2023 Mar 17;15(6):1455. doi: 10.3390/nu15061455.
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Intestinal microbiota: A promising therapeutic target for hypertension.肠道微生物群：高血压的一个有前景的治疗靶点。
Front Cardiovasc Med. 2022 Nov 15;9:970036. doi: 10.3389/fcvm.2022.970036. eCollection 2022.
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Infection Induces Intestinal Dysbiosis That Could Be Related to the Onset of Atherosclerosis.感染会引起肠道菌群失调，这可能与动脉粥样硬化的发生有关。
Biomed Res Int. 2022 Oct 22;2022:9943158. doi: 10.1155/2022/9943158. eCollection 2022.
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Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM-1 in rats.三甲胺，一种肠道细菌代谢物和空气污染物，可增加大鼠的血压和肾脏损伤标志物，包括蛋白尿和 KIM-1。
J Transl Med. 2022 Oct 15;20(1):470. doi: 10.1186/s12967-022-03687-y.