Humphrey P A, Lee C M, Ashraf M
Department of Biology, Howard University, Washington, DC 20059.
J Natl Med Assoc. 1994 Aug;86(8):613-9.
A metabolic imbalance technique was used to study the effects of zinc deficiency on immunoglobulin levels in mice infected with Trypanosoma musculi or immunized with parasite products. Zinc-deficient mice developed higher numbers of parasitemia earlier and exhibited prolonged infection. Irrespective of the diet, higher IgG1, IgG2b, and IgM levels, lower IgG2a and IgA levels, and uniform IgG3 levels were exhibited primarily by mice infected with T musculi and to a lesser extent by mice immunized with parasite products. Zinc-deficient mice showed smaller increases in IgG1 and IgM, but larger gains in IgG2b compared with mice on full-complement and pair-fed diets. However, IgG2a decreased significantly in zinc-deficient mice.
采用代谢失衡技术研究锌缺乏对感染鼠锥虫或用寄生虫产物免疫的小鼠免疫球蛋白水平的影响。缺锌小鼠较早出现较高的寄生虫血症数量，并表现出感染时间延长。无论饮食如何，感染鼠锥虫的小鼠主要表现出较高的IgG1、IgG2b和IgM水平，较低的IgG2a和IgA水平，以及均匀的IgG3水平，用寄生虫产物免疫的小鼠表现程度较小。与全补充饮食和配对喂养饮食的小鼠相比，缺锌小鼠的IgG1和IgM增加较小，但IgG2b增加较大。然而，缺锌小鼠的IgG2a显著降低。
