大豆异黄酮对认知功能的影响：随机对照试验的系统评价和荟萃分析。
Effects of soy isoflavones on cognitive function: a systematic review and meta-analysis of randomized controlled trials.
机构信息
C. Cui, L. Kuller, and A. Sekikawa are with the Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
R. Birru is with the Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
出版信息
Nutr Rev. 2020 Feb 1;78(2):134-144. doi: 10.1093/nutrit/nuz050.
CONTEXT
The results of preclinical and observational studies support the beneficial effect of soy isoflavones on cognition.
OBJECTIVE
This review aimed to evaluate the effects of soy isoflavones on cognition in adults.
DATA SOURCES
The PUBMED, EMBASE, Ovid Medline, Cochrane Library, and clinicaltrials.gov databases were searched.
STUDY SELECTION
Two researchers independently screened 1955 records, using the PICOS criteria: participants were adults; intervention was dietary sources with soy isoflavones or isolated soy isoflavones; comparator was any comparator; outcome was cognitive function; study type was randomized controlled trials (RCTs). A third researcher was consulted to resolve any discrepancies. Sixteen RCTs were included and their quality assessed.
DATA EXTRACTION
Information on study design, characteristics of participants, and outcomes was extracted. PRISMA guidelines were followed.
DATA ANALYSIS
A random-effects meta-analysis was used to pool estimates across studies. In the 16 RCTs (1386 participants, mean age = 60 y), soy isoflavones were found to improve overall cognitive function (standardized mean difference [SMD], 0.19; 95% confidence interval [CI], 0.07-0.32) and memory (SMD, 0.15; 95%CI, 0.03-0.26).
CONCLUSION
The results showed that soy isoflavones may improve cognitive function in adults.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO registration no. CRD42018082070.
背景
临床前和观察性研究的结果支持大豆异黄酮对认知有益。
目的
本综述旨在评估大豆异黄酮对成年人认知的影响。
资料来源
检索 PUBMED、EMBASE、Ovid Medline、Cochrane 图书馆和 clinicaltrials.gov 数据库。
研究选择
两名研究人员使用 PICOS 标准独立筛选了 1955 条记录：参与者为成年人；干预措施为饮食来源的大豆异黄酮或分离的大豆异黄酮；对照为任何对照；结果为认知功能；研究类型为随机对照试验（RCT）。如有任何分歧，将咨询第三名研究人员。纳入了 16 项 RCT，并对其质量进行了评估。
资料提取
提取了研究设计、参与者特征和结果的信息。遵循 PRISMA 指南。
资料分析
使用随机效应荟萃分析对研究间的估计值进行汇总。在 16 项 RCT 中（1386 名参与者，平均年龄 60 岁），发现大豆异黄酮可改善整体认知功能（标准化均数差 [SMD]，0.19；95%置信区间 [CI]，0.07-0.32）和记忆力（SMD，0.15；95%CI，0.03-0.26）。
结论
结果表明，大豆异黄酮可能改善成年人的认知功能。
系统评价注册
PROSPERO 注册号 CRD42018082070。
Zotero 插件