Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Food Res Int. 2020 Nov;137:109578. doi: 10.1016/j.foodres.2020.109578. Epub 2020 Jul 21.
Soy products and isoflavones intake have been shown to exert antioxidant effects. There are several randomized control trials (RCTs) that evaluated the effect of soy products intake on oxidative stress (OS) parameters. The aim of the present systematic review and meta-analysis was to summarize the results of RCTs evaluating the effect of soy products and isoflavones intake on OS parameters. Randomized trials that assessed the effect of soy products and isoflavones intake on OS parameters in adults were identified through searching in electronic databases: Cochrane clinical trial center, Embase, PubMed, Scopus, and Web of Sciences up to April 2020. Random effects model was used to calculate the effects sizes of soy intake on OS parameters. Twenty-four trials with 1,852 participants were eligible and were included in the meta-analysis which measured OS parameters. Soy intake compared to control group significantly reduced MDA levels (SMD: -0.53; 95% CI: -0.86, -0.19; I = 88.3%), increased GSH levels (SMD: 0.51; 95% CI: 0.13, 0.88; I = 72.4%), SOD activity (SMD: 0.53; 95% CI: 0.08, 0.99; I = 84.1%), TAC (SMD: 0.54; 95% CI: 0.27, 0.82; I = 49.3%) and TRAP (SMD: 1.74; 95% CI: 0.82, 2.65; I = 81.3%) significantly compared to control group. Soy products and isoflavones intake are effective in improving OS parameters in adults compared with controls; thus, it could be a valuable advise to control OS progress in chronic diseases.
大豆制品和异黄酮的摄入已被证明具有抗氧化作用。有几项随机对照试验（RCT）评估了大豆制品摄入对氧化应激（OS）参数的影响。本系统评价和荟萃分析的目的是总结评估大豆制品和异黄酮摄入对 OS 参数影响的 RCT 结果。通过在电子数据库中搜索，确定了评估大豆制品和异黄酮摄入对成年人 OS 参数影响的随机试验：Cochrane 临床试验中心、Embase、PubMed、Scopus 和 Web of Sciences，截至 2020 年 4 月。使用随机效应模型计算大豆摄入量对 OS 参数的影响大小。共有 24 项试验，涉及 1852 名参与者，符合纳入荟萃分析的条件，该分析测量了 OS 参数。与对照组相比，大豆摄入显著降低 MDA 水平（SMD：-0.53；95%CI：-0.86，-0.19；I=88.3%），增加 GSH 水平（SMD：0.51；95%CI：0.13，0.88；I=72.4%）、SOD 活性（SMD：0.53；95%CI：0.08，0.99；I=84.1%）、TAC（SMD：0.54；95%CI：0.27，0.82；I=49.3%）和 TRAP（SMD：1.74；95%CI：0.82，2.65；I=81.3%）显著高于对照组。与对照组相比，大豆制品和异黄酮的摄入能有效改善成年人的 OS 参数；因此，这可能是控制慢性病中 OS 进展的一个有价值的建议。
