Coetzer Andre, Scott Terence P, Noor Khadija, Gwenhure Lambert F, Nel Louis H
Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa.
Global Alliance for Rabies Control SA NPC, Pretoria 0181, South Africa.
Vaccines (Basel). 2019 Sep 9;7(3):108. doi: 10.3390/vaccines7030108.
The elimination of canine rabies through the implementation of high coverage mass dog vaccination campaigns is a complex task, particularly in the resource-limited countries of the rabies endemic world. Here we demonstrated the feasibility of applying targeted rabies vaccination campaigns to deliver more impactful intervention campaigns in resource-limited settings using evidence and lessons learnt from other diseases. With the use of strategic rabies intervention programs, we demonstrate the noteworthy reduction of rabies cases in two very different African settings. The strategic intervention was most significantly aided by the use of a custom-developed vaccination tracking device (the Global Alliance for Rabies Control (GARC) Data Logger) and an integrated rabies surveillance system (the Rabies Epidemiological Bulletin). Our first case study, an island-wide strategic dog vaccination on Tanzania's Unguja island, reduced the incidence of rabies by 71% in the first 16 months of implementation. In the second case study, a similar approach was applied in the metropolitan capital city of Zimbabwe and the incidence of rabies declined by 13% during the first 13 months of implementation. The methodologies and results presented here suggest that, in resource-limited settings, an optimal approach towards the elimination of dog rabies would revolve around strategic interventions, subject to the use of appropriate planning, surveillance, and vaccination tools.
通过开展高覆盖率的大规模犬类疫苗接种运动来消除犬狂犬病是一项复杂的任务,尤其是在狂犬病流行的资源有限国家。在此,我们利用从其他疾病中获得的证据和经验教训,证明了在资源有限的环境中开展有针对性的狂犬病疫苗接种运动以提供更具影响力的干预行动的可行性。通过实施战略性狂犬病干预计划,我们展示了在非洲两个截然不同的地区狂犬病病例显著减少的情况。战略性干预最显著地得益于使用定制开发的疫苗接种追踪设备(狂犬病控制全球联盟(GARC)数据记录器)和综合狂犬病监测系统(《狂犬病流行病学公报》)。我们的第一个案例研究是在坦桑尼亚的恩古贾岛开展全岛范围的战略性犬类疫苗接种,在实施的前16个月内狂犬病发病率降低了71%。在第二个案例研究中,在津巴布韦的首都大都市采用了类似方法,在实施的前13个月内狂犬病发病率下降了13%。此处介绍的方法和结果表明,在资源有限的环境中,消除犬狂犬病的最佳方法将围绕战略性干预展开,前提是使用适当的规划、监测和疫苗接种工具。