Li Jun-Yi, Sun Fei, Zhou Hai-Feng, Yang Jia, Huang Cong, Fan Heng
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Pharmacol. 2019 Aug 23;10:930. doi: 10.3389/fphar.2019.00930. eCollection 2019.
Glucomannan, long recognized as the active ingredient of the traditional Chinese medicinal herb Konjac glucomannan, is a naturally occurring polysaccharide existing in certain plant species and fungi. Due to its special property to also serve as a dietary supplement, glucomannan has been widely applied in clinic to lower body weight and circulation cholesterol level and to treat constipation, diabetes, and arterial sclerosis. Besides the regulatory role engaged with gastroenterological and metabolic syndrome, recently, its therapeutic effect and the underlying mechanisms in treating cancerous diseases have been appreciated by mounting researches. The present review aims to emphasize the multifaceted aspects of how glucomannan exerts its anti-tumor function.
葡甘露聚糖长期以来被认为是传统中草药魔芋葡甘露聚糖的活性成分，是一种存在于某些植物物种和真菌中的天然多糖。由于其还具有作为膳食补充剂的特殊性质，葡甘露聚糖已在临床上广泛应用于降低体重和循环胆固醇水平，以及治疗便秘、糖尿病和动脉粥样硬化。除了在胃肠病学和代谢综合征方面的调节作用外，最近，越来越多的研究认识到其在治疗癌症疾病方面的治疗效果及其潜在机制。本综述旨在强调葡甘露聚糖发挥其抗肿瘤功能的多方面情况。
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