The miR-195 Axis Regulates Chemoresistance through TUBB and Lung Cancer Progression through BIRC5.

Chemoresistance and metastasis are the major reasons for non-small cell lung cancer (NSCLC) treatment failure and patient deaths. We and others have shown that miR-195 regulates the sensitivity of NSCLC to microtubule-targeting agents (MTAs) and and that miR-195 represses the migration and invasion of NSCLC cells . However, the relationship between miR-195 and microtubule structure and function and whether miR-195 represses NSCLC metastasis remain unknown. We assessed the correlation between tumor levels of and patient survival, the effect of TUBB on drug response, and the effect of miR-195 on migration, invasion, and metastasis and . We found that miR-195 directly targets ; knockdown of sensitizes cells to MTAs, while overexpression confers resistance; high expression of is correlated with worse survival of lung adenocarcinoma; TUBB is also regulated by CHEK1, which has been shown to regulate chemoresistance; and miR-195 targets to repress migration and invasion and metastasis . Our findings highlight the relevance of the miR-195/TUBB axis in regulating the response of NSCLC to MTAs and the importance of the miR-195/BIRC5 axis in regulating NSCLC metastasis.