Raz I, Havivi E
Department of Medicine B, Hadassah University Hospital, Ein Karem, Jerusalem, Israel.
Diabetes Res. 1988 Jan;7(1):19-23.
The influence of chronic diabetes on zinc, copper and chromium status in the urine, plasma, liver, kidney, bone, muscle, lymphocytes and erythrocytes was investigated in rats 180 days after streptozotocin injection, in comparison to age matched normal rats. The concentration and tissue content of zinc and copper were increased significantly in the liver, femur, erythrocyte and lymphocyte of the diabetic rats in addition to an increase in their urinary loss. In contrast, the concentration of zinc, copper and chromium in the kidney of the diabetic rats and the concentration of copper in the muscle and of chromium in the liver of the diabetic rats were similar to those of the normal rats. There was also a marked deficiency of zinc in the muscle and of chromium in the bone of the diabetic rats. The potential significance of altered trace metal metabolism during long term changes in endocrine status, and the possible explanation and significance of the variable concentrations of essential metals in different organs of streptozotocin induced chronic diabetic rats is discussed. The importance of erythrocyte and leukocyte zinc concentration as a mirror to their relative concentration in other tissue of animals and humans with type I diabetes is raised.
在注射链脲佐菌素180天后的大鼠中，研究了慢性糖尿病对尿液、血浆、肝脏、肾脏、骨骼、肌肉、淋巴细胞和红细胞中锌、铜和铬状态的影响，并与年龄匹配的正常大鼠进行比较。除了尿中锌和铜的流失增加外，糖尿病大鼠肝脏、股骨、红细胞和淋巴细胞中锌和铜的浓度及组织含量显著增加。相比之下，糖尿病大鼠肾脏中锌、铜和铬的浓度，以及糖尿病大鼠肌肉中铜的浓度和肝脏中铬的浓度与正常大鼠相似。糖尿病大鼠的肌肉中锌和骨骼中铬也存在明显缺乏。讨论了内分泌状态长期变化期间微量金属代谢改变的潜在意义，以及链脲佐菌素诱导的慢性糖尿病大鼠不同器官中必需金属浓度变化的可能解释和意义。还提出了红细胞和白细胞锌浓度作为反映I型糖尿病动物和人类其他组织中相对浓度的重要性。
