University of Edinburgh, College of Medicine and Veterinary Medicine, Edinburgh, United Kingdom .
Universidade de Sorocaba, Programa de Pós-graduação em Ciências Farmacêuticas, Sorocaba, SP, Brasil.
Rev Soc Bras Med Trop. 2019 Sep 5;52:e20190232. doi: 10.1590/0037-8682-0232-2019.
Dengue is an endemic and epidemic disease in Brazil, with a high burden of disease. Amazonas State has a high risk of transmission. This study aimed to assess the self-reported prevalence of dengue in adults living in Manaus Metropolitan Region.
A cross-sectional study was conducted with adults living in Manaus Metropolitan Region in 2015. We performed a three-phase probabilistic sampling to collect participants' clinical and sociodemographic data. Self-reported dengue infection in the previous year was the primary outcome. Descriptive statistics and Poisson regression analysis with robust variance were used to calculate the prevalence ratio (PR) of dengue infections with 95% confidence intervals (95% CIs). Multilevel analysis including city and neighborhood variables was calculated. All analyses considered the complex sampling.
Among the 4,001 participants, dengue in the previous year was self-reported by 7.0% (95% CI 6.3%-7.8%). Dengue was more frequent in women(PR 1.51; 95% CI 1.06-2.13), elderly participants (≥60 years old, PR 2.54; 95% CI 1.19-5.45), White and Asian participants (PR, 1.57; 95% CI, 1.11-2.23), and individuals who had not received endemic agent visits (PR, 2.28; 95% CI, 1.31-3.99). After multilevel analysis, sex was no longer a significant variable, with the remaining associations still significant.
Seven out of 100 inhabitants of Manaus Metropolitan Region reported dengue in the previous year. Dengue was predominantly observed in women, elderly individuals, White and Asian individuals, and individuals who did not receive endemic agent visits. The setting plays an important role in dengue infections.
登革热是巴西的地方性和流行性疾病，疾病负担沉重。亚马逊州有很高的传播风险。本研究旨在评估居住在马瑙斯大都市区的成年人自我报告的登革热流行率。
这是一项 2015 年在马瑙斯大都市区进行的成年人横断面研究。我们采用三阶段概率抽样收集参与者的临床和社会人口学数据。自我报告的前一年登革热感染是主要结局。使用描述性统计和具有稳健方差的 Poisson 回归分析计算 95%置信区间（95%CI）的登革热感染患病率比（PR）。计算包括城市和社区变量的多层分析。所有分析均考虑了复杂抽样。
在 4001 名参与者中，7.0%（95%CI 6.3%-7.8%）自我报告前一年患有登革热。女性（PR 1.51；95%CI 1.06-2.13）、老年参与者（≥60 岁，PR 2.54；95%CI 1.19-5.45）、白人和亚洲参与者（PR 1.57；95%CI 1.11-2.23）以及未接受地方性病原体访问的个体中，登革热更为常见。多水平分析后，性别不再是一个显著变量，其余关联仍然显著。
马瑙斯大都市区每 100 名居民中有 7 人报告前一年患有登革热。登革热主要发生在女性、老年人、白人和亚洲人以及未接受地方性病原体访问的个体中。环境在登革热感染中起着重要作用。
