Ir-Catalyzed Regiocontrolled Allylic Amination of Di-/Trienyl Allylic Alcohols with Secondary Amines.

An unprecedented regio-controllable allylic amination of unactivated dienyl and trienyl allylic alcohols has been developed, providing an efficient approach toward the site-selective formation of C1-, C3-, and C5-/C7-amination products from the sole substrates. Key to this protocol is the use of secondary amines as the amination reagents, as well as the presence of an iridium catalyst and scandium triflate.