富含白皮杉醇的西番莲籽提取物对人乙二醛酶I介导的癌细胞生长的影响。
Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I-mediated cancer cell growth.
作者信息
Yamamoto Takayuki, Sato Akira, Takai Yusuke, Yoshimori Atsushi, Umehara Masahiro, Ogino Yoko, Inada Mana, Shimada Nami, Nishida Aya, Ichida Risa, Takasawa Ryoko, Maruki-Uchida Hiroko, Mori Sadao, Sai Masahiko, Morita Minoru, Tanuma Sei-Ichi
机构信息
Research and Development Institute, Health Science Research Center, Morinaga and Company Limited, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama, 230-8504, Japan.
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.
出版信息
Biochem Biophys Rep. 2019 Aug 30;20:100684. doi: 10.1016/j.bbrep.2019.100684. eCollection 2019 Dec.
Passion fruit seed extract (PFSE), a product rich in stilbenes such as piceatannol and scirpusin B, has various physiological effects. It is unclear whether PFSE and its stilbene derivatives inhibit cancer cell proliferation via human glyoxalase I (GLO I), the rate-limiting enzyme for detoxification of methylglyoxal. We examined the anticancer effects of PFSE in two types of human cancer cell lines with different GLO I expression levels, NCI-H522 cells (highly-expressed GLO I) and HCT116 cells (lowly-expressed GLO I). PFSE and its stilbenes inhibited GLO I activity. In addition, PFSE and its stilbenes supressed the cancer cell proliferation of NCI-H522 cells more than HCT116 cells. These observations suggest that PFSE can provide a novel anticancer strategy for prevention and treatment.
西番莲籽提取物（PFSE）是一种富含诸如白皮杉醇和水麦冬素B等芪类化合物的产品，具有多种生理效应。目前尚不清楚PFSE及其芪类衍生物是否通过人体乙二醛酶I（GLO I）来抑制癌细胞增殖，人体乙二醛酶I是甲基乙二醛解毒的限速酶。我们研究了PFSE在两种GLO I表达水平不同的人类癌细胞系中的抗癌作用，即NCI-H522细胞（GLO I高表达）和HCT116细胞（GLO I低表达）。PFSE及其芪类化合物抑制了GLO I的活性。此外，PFSE及其芪类化合物对NCI-H522细胞癌细胞增殖的抑制作用比对HCT116细胞更强。这些观察结果表明，PFSE可为癌症的预防和治疗提供一种新的抗癌策略。
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