Department of Diabetology and Endocrinology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan.
Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan.
Nutrients. 2017 Oct 18;9(10):1142. doi: 10.3390/nu9101142.
Animal studies have shown the beneficial effects of piceatannol on metabolic health; however, there is a lack of human studies designed to examine these effects. The objective of this study was to investigate the effects of piceatannol on metabolic health in humans. This randomized, placebo-controlled study was conducted on 39 subjects, including 10 overweight men and 9 overweight women (BMI ≥ 25), as well as 10 non-overweight men and 10 non-overweight women (BMI < 25). Subjects received piceatannol (20 mg/day) or placebo capsules for eight weeks in a random order. The primary outcome was the effect of piceatannol on glucose-metabolism, including insulin sensitivity. The secondary outcomes were the effects on other parameters, including blood pressure (BP), heart rate (HR), endothelial function, lipids, inflammation, oxidative stress, mood status, and Sirt1 and phospho-AMP-activated kinase (p-AMPK) expression in isolated peripheral blood mononuclear cells (PBMNCs). Supplementation with piceatannol in overweight men reduced serum insulin levels, HOMA-IR, BP and HR. Other groups, including non-overweight men, as well as overweight and non-overweight women, showed no beneficial effects on insulin sensitivity, BP and HR. Furthermore, piceatannol is not associated with other data, including body weight (BW), body composition, endothelial function, lipids, inflammation, oxidative stress, mood status, and Sirt1/p-AMPK expression in PBMNCs. In conclusion, supplementation with piceatannol can improve metabolic health, including insulin sensitivity, BP and HR, in overweight men.
动物研究表明白皮杉醇对代谢健康有益；然而，缺乏旨在研究这些影响的人体研究。本研究旨在研究白皮杉醇对人体代谢健康的影响。这是一项随机、安慰剂对照研究，共纳入 39 名受试者，包括 10 名超重男性和 9 名超重女性（BMI≥25），以及 10 名非超重男性和 10 名非超重女性（BMI<25）。受试者随机接受白皮杉醇（20mg/天）或安慰剂胶囊治疗 8 周。主要结局是白皮杉醇对葡萄糖代谢的影响，包括胰岛素敏感性。次要结局是对其他参数的影响，包括血压（BP）、心率（HR）、内皮功能、血脂、炎症、氧化应激、情绪状态以及分离外周血单个核细胞（PBMNC）中的 Sirt1 和磷酸 AMP 激活的蛋白激酶（p-AMPK）表达。在超重男性中补充白皮杉醇可降低血清胰岛素水平、HOMA-IR、BP 和 HR。其他组，包括非超重男性以及超重和非超重女性，对胰岛素敏感性、BP 和 HR 没有有益影响。此外，白皮杉醇与其他数据无关，包括体重（BW）、身体成分、内皮功能、血脂、炎症、氧化应激、情绪状态以及 PBMNC 中的 Sirt1/p-AMPK 表达。总之，补充白皮杉醇可以改善超重男性的代谢健康，包括胰岛素敏感性、BP 和 HR。
