偏头痛患者的单胺氧化酶活性、血清素代谢与血小板聚集：一项初步研究。
MAO activity, serotonin metabolism and aggregation of platelets from migraine patients. A preliminary study.
作者信息
Kovács K, Tóthfalusi L, Hermán F, Magyar K
机构信息
Dept. of Neurology, Semmelweis University of Medicine, Budapest, Hungary.
出版信息
Pol J Pharmacol Pharm. 1988 Nov-Dec;40(6):691-5.
Platelets of migraine patients showed abnormal behavior such as hyperaggregability and reduced monoamine oxidase activity (MAO). We measured the MAO activity, serotonin (5-HT) content and release, adenosine diphosphate (ADP)-induced aggregation, and the prostacyclin (PGI2) antiaggregatory effect using the same sample of platelets from migraine patients to find out if these characteristics are intercorrelated. A significant correlation between MAO activity and sensitivity to PGI2 was found.
偏头痛患者的血小板表现出异常行为，如高聚集性和单胺氧化酶活性（MAO）降低。我们使用偏头痛患者相同的血小板样本测量了MAO活性、血清素（5-HT）含量及释放、二磷酸腺苷（ADP）诱导的聚集以及前列环素（PGI2）的抗聚集作用，以查明这些特征是否相互关联。结果发现MAO活性与对PGI2的敏感性之间存在显著相关性。
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