Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel.
Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel.
Carbohydr Polym. 2019 Dec 1;225:115249. doi: 10.1016/j.carbpol.2019.115249. Epub 2019 Aug 26.
The development of a polymer-nanogel hydrogel based on a pair of polysaccharides is reported for the first time. This new hydrogel exhibits self-healing properties due to physical interactions between soluble pectin chains and chitosan nanogels. The nanogels act as crosslinking agents between pectin chains, leading to the formation of thermos-responsive hydrogel. Due to the dynamic interactions between the chains and the nanogels, the formed network dissociate under applied shear, allowing the hydrogel to flow. Moreover, elimination of the applied shear results in exceptionally fast and comprehensive recovery of the storage modulus, reverting the mixture back into solid form. The viscosity and Young modulus increased with the nanogels concentration while the equilibrium swelling decreased as the nanogels concentration increased suggesting a direct relation between the cross-linking degree and nanogel content. This novel hydrogel displays network recovery suitable for injectable biomedical applications, while benefiting from the advantages of nanogels as carriers.
首次报道了一种基于一对多糖的聚合物-纳米凝胶水凝胶的开发。由于可溶性果胶链和壳聚糖纳米凝胶之间的物理相互作用，这种新的水凝胶具有自修复性能。纳米凝胶作为果胶链之间的交联剂，导致形成温敏水凝胶。由于链和纳米凝胶之间的动态相互作用，在施加的剪切下形成的网络会解离，从而使水凝胶能够流动。此外，消除施加的剪切会导致储能模量异常快速和全面地恢复，使混合物重新回到固体状态。随着纳米凝胶浓度的增加，粘度和杨氏模量增加，而平衡溶胀度随着纳米凝胶浓度的增加而降低，这表明交联度与纳米凝胶含量之间存在直接关系。这种新型水凝胶显示出适合可注射生物医学应用的网络恢复性能，同时受益于纳米凝胶作为载体的优势。
