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用于组织工程应用的甲基丙烯酸化海藻酸盐的静电纺丝

Electrospinning of methacrylated alginate for tissue engineering applications.

作者信息

Poshina Daria, Sokolova Natalia, Nono-Tagne Steve, Ahmadi-Nohadani Hamed, Gofman Iosif, Mishanin Alexander, Golovkin Alexey, Skorik Yury, Otsuka Issei

机构信息

Institute of Macromolecular Compounds, Branch of Petersburg Nuclear Physics Institute named by B.P. Konstantinov, National Research Centre Kurchatov Institute Bolshoy pr. V.O. 31 199004 St Petersburg Russia

Univ. Grenoble Alpes, CNRS CERMAV Grenoble 38000 France

出版信息

RSC Adv. 2024 Dec 9;14(52):38746-38756. doi: 10.1039/d4ra07559e. eCollection 2024 Dec 3.

DOI:10.1039/d4ra07559e
PMID:39654914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11626522/
Abstract

Photo-crosslinkable methacrylated alginate derivatives (M-ALGs) were synthesized modification of sodium alginate with glycidyl methacrylate. Needle (capillary) and needleless electrospinning techniques were employed to produce their nonwoven fiber mats. Spinning parameters such as applied voltage, solution composition, and flow rate were optimized to form uniform bead-free fibers with an average diameter of about 150 nm. The needleless technique allowed successful electrospinning of M-ALG solutions with wider ranges of viscosities and surface tensions owing to its higher applicable voltage (∼65 kV) compared to that of the needle technique (∼30 kV). Photo-crosslinking of the fibers UV irradiation allowed the fiber mats to remain insoluble in physiological media while maintaining their mechanical properties. Cultivation of multipotent mesenchymal stem cells (MSCs) with the cross-linked fiber mats in a modified Eagle medium (α-MEM) showed the growth of spherical colonies, indicating the sufficient cytocompatibility of the fiber mats with MSCs.

摘要

通过甲基丙烯酸缩水甘油酯对海藻酸钠进行改性，合成了可光交联的甲基丙烯酸化海藻酸盐衍生物（M-ALGs）。采用针式（毛细管）和无针静电纺丝技术制备其非织造纤维垫。对施加电压、溶液组成和流速等纺丝参数进行了优化，以形成平均直径约为150 nm的均匀无珠纤维。由于无针技术的适用电压（约65 kV）高于针式技术（约30 kV），因此无针技术能够成功地对粘度和表面张力范围更广的M-ALG溶液进行静电纺丝。通过紫外线照射对纤维进行光交联，使纤维垫在保持其机械性能的同时，仍不溶于生理介质。在改良的伊格尔培养基（α-MEM）中，用交联纤维垫培养多能间充质干细胞（MSCs），结果显示形成了球形集落，表明纤维垫与MSCs具有足够的细胞相容性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/b43e0297d542/d4ra07559e-f7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/f95cb1c77768/d4ra07559e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/b793b355b739/d4ra07559e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/8e2e5a2a2373/d4ra07559e-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/b43e0297d542/d4ra07559e-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/5b0231b5860c/d4ra07559e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/1e7ade92808f/d4ra07559e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/33a6563a367d/d4ra07559e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/86c8dff43c1c/d4ra07559e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/f95cb1c77768/d4ra07559e-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/b793b355b739/d4ra07559e-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/8e2e5a2a2373/d4ra07559e-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cb/11626522/b43e0297d542/d4ra07559e-f7.jpg

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